Document Detail

Skin irritancy of commercially available alkyl ether sulphate surfactants: is there a difference between those with alkyl chains consisting of even or odd numbers of carbon atoms?
MedLine Citation:
PMID:  2847369     Owner:  NLM     Status:  MEDLINE    
Various concentrations of commercially available alkyl ether sulphate surfactants with alkyl chains consisting of even or odd numbers of carbon atoms have been tested for their primary irritancy to rabbit skin in vivo. All six surfactants (2 with even and 4 with odd carbon number) produced skin irritation. The level of irritation showed dose-dependent increases in the concentration range 4-12% (w/w), with a plateauing of responses of moderate to severe irritation occurring between 12 and 24% (w/w). Recovery generally took 10-14 days to occur. There were no significant differences in the intensity or duration of response between surfactants with alkyl chains consisting of even and odd numbers of carbon atoms.
M A Pemberton; C Rhodes
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Toxicology letters     Volume:  44     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-16     Completed Date:  1988-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Imperial Chemical Industries PLC, Central Toxicology Laboratory, Macclesfield, Cheshire, U.K.
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MeSH Terms
Alkanesulfonates / toxicity*
Skin / drug effects*
Structure-Activity Relationship
Surface-Active Agents / toxicity*
Reg. No./Substance:
0/Alkanesulfonates; 0/Irritants; 0/Surface-Active Agents

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