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SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA.
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MedLine Citation:
PMID:  19868979     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Cultures of a hemolytic streptococcus isolated from a human case of erysipelas were tested for ability to produce lesions by injecting various amounts intradermally in shaved rabbits. Severe lesions could be developed at will in this way despite the fact that intravenous or intraperitoneal inoculations of large doses of the cultures failed to kill. The lesions were of two sorts, phlegmonous and erysipelas-like. A serum capable of warding off the injurious action of the streptococcus on the skin was procured from animals receiving repeated intracutaneous inoculations of the organism. Normal serum by contrast had no protective effect. By intradermal injections at several points in the same normal rabbit of small quantities of mixtures of equal parts of serum and various dilutions of a suspension of streptococci it proved possible to test sera for the presence of substances protective against the streptococcus.
Authors:
T M Rivers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  41     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1925 Jan 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  -    
Affiliation:
Hospital of The Rockefeller Institute for Medical Research.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1925, by The Rockefeller Institute for Medical Research New York
Received Day: 9 Month: 9 Year: 1924
Print publication date: Day: 31 Month: 1 Year: 1925
Volume: 41 Issue: 2
First Page: 179 Last Page: 184
ID: 2130937
PubMed Id: 19868979

SKIN INFECTION OF RABBITS WITH HEMOLYTIC STREPTOCOCCI ISOLATED FROM A PATIENT WITH ERYSIPELAS : I. METHOD OF DEMONSTRATING PROTECTIVE ACTION OF IMMUNE SERA.
Thomas M. Rivers
From the Hospital of The Rockefeller Institute for Medical Research.


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