Document Detail

Skin-induced tolerance and its reversal by Toll-like receptor ligands.
MedLine Citation:
PMID:  17557146     Owner:  NLM     Status:  MEDLINE    
In 1970, Gershon was the first to propose that T cells, in addition to their helper activity, can also play a role as regulatory cells capable of suppressing immune responses. However, the initial strong interest in T cell-mediated suppression was followed by a period of doubt and skepticism. Since the late 1990 s the "S" word started to be used in immunology again and interest in T suppressor cells has grown, ushering in a new renaissance for the field. In this article the author presents the current knowledge about a new subject called "skin-induced tolerance". Suppression is induced via epicutaneous immunization and is described in both Th1- and Tc1-mediated contact sensitivity reactions. The subject of skin-induced tolerance is also considered in the regulation of experimental models of autoimmune diseases such as allergic autoimmune encephalomyelitis and collagen-induced arthritis and finally in an animal model of graft rejection. The last part of this presentation will introduce the very fresh subject of "contrasuppression", or the reversal of skin-induced suppression.
Marian Szczepanik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-06-08
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  55     ISSN:  0004-069X     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  161-72     Citation Subset:  IM    
Department of Human Developmental Biology, Jagiellonian University, College of Medicine, Kopernika 7, 31-034, Kraków, Poland.
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MeSH Terms
Administration, Cutaneous
Dermatitis, Contact / immunology*,  metabolism
Dose-Response Relationship, Immunologic
Immune Tolerance / immunology*
Lymphokines / immunology*,  metabolism
Skin / immunology*
T-Lymphocyte Subsets / immunology,  metabolism
T-Lymphocytes, Regulatory / immunology*,  metabolism
Toll-Like Receptors / immunology*,  metabolism
Reg. No./Substance:
0/Ligands; 0/Lymphokines; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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