Document Detail

Skin-homing T cells in human cutaneous allergic inflammation.
MedLine Citation:
PMID:  8722046     Owner:  NLM     Status:  MEDLINE    
The cutaneous lymphocyte-associated antigen (CLA) is a carbohydrate epitope present on memory/effector T cells that infiltrate inflamed skin. E-selectin is the ligand for CLA and is induced under inflammation on endothelial cells. CLA was originally postulated as a phenotype marker for skin-associated T cells. We studied the specific in vitro response to skin-associated allergens of CLA+ and CLA-CD45RO+ T cells in atopic dermatitis (AD) and contact dermatitis (CD), which represent two well-characterized T cell-mediated cutaneous allergic inflammations. Whereas CLA+ T cells from AD patients preferentially responded to house dust mite (HDM) and CLA+ T cells from nickel CD patients showed an increased response to nickel, CLA-T cells showed very little response in both cases. In contrast, tetanus toxoid, a systemically acting antigen, induced a proliferative response in both CLA+ and CLA- cells. Interestingly the response to HDM in patients with asthma +/- AD was preferentially found in the CLA- subset indicating the involvement of different homing receptors for mucosal tissues. Moreover, CLA+ T cells showed enhanced migration through activated human umbilical vein endothelial cell monolayers compared to CLA- T cells. The CLA binding to E-selectin is initially responsible for the extravasation that also involves VLA-4/VCAM-1 and LFA-1/ICAM-1 interactions. We have recently identified IL-8 as an endothelial cell-derived chemokine and the IL-8 receptor type B which control CLA+ T cell migration. Such a CLA-mediated migration would localize memory/effector T cells that respond to antigens and reach the body through inflamed skin. Our data support the existence of a regionalization of the immune system and in particular of the skin immune system. It may allow an efficient distribution of the immune defense to different sites of the body.
L F Santamaria Babi; M T Perez Soler; C Hauser; K Blaser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunologic research     Volume:  14     ISSN:  0257-277X     ISO Abbreviation:  Immunol. Res.     Publication Date:  1995  
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8611087     Medline TA:  Immunol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-24     Citation Subset:  IM    
Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland.
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MeSH Terms
Antigens, CD3 / biosynthesis,  immunology
Antigens, CD45 / biosynthesis,  immunology
Antigens, Neoplasm
Dermatitis, Atopic / immunology*
Dermatitis, Contact / immunology*
E-Selectin / immunology
Epitopes / immunology
Immunologic Memory
Intercellular Adhesion Molecule-1 / biosynthesis,  immunology
Interleukin-8 / immunology
Lymphocyte Function-Associated Antigen-1 / biosynthesis,  immunology
Membrane Glycoproteins / biosynthesis,  immunology*
Mites / immunology
Nickel / immunology
T-Lymphocytes / immunology*
Vascular Cell Adhesion Molecule-1 / biosynthesis,  immunology
Reg. No./Substance:
0/Antigens, CD3; 0/Antigens, Neoplasm; 0/CTAGE1 protein, human; 0/E-Selectin; 0/Epitopes; 0/Interleukin-8; 0/Lymphocyte Function-Associated Antigen-1; 0/Membrane Glycoproteins; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 7440-02-0/Nickel; EC, CD45

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