Document Detail

Skin-homing T cells in cutaneous allergic inflammation.
MedLine Citation:
PMID:  16354951     Owner:  NLM     Status:  MEDLINE    
The involvement of circulating cutaneous lymphocyte-associated (CLA)+ T cells in skin allergy was initially described in atopic and contact dermatitis in a series of experiments performed in Davos, at the Swiss Institute of Allergy and Asthma Research. Since then, numerous studies have confirmed and extended those initial findings. Both basic and clinical research data obtained on this subset of memory T cells support a relevant role of CLA+ T cells in the regional cutaneous immune system. The spectrum of cutaneous diseases where CLA+ T cells have been shown to play a relevant role has expanded far beyond the field of allergy, highlighting the relevance of this memory T-cell subpopulation in cutaneous diseases. The goal of this chapter is to review known features of those cells in atopic dermatitis, contact dermatitis and nonimmediate cutaneous allergic reactions to drugs.
Luis F Santamaria-Babi
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chemical immunology and allergy     Volume:  91     ISSN:  1660-2242     ISO Abbreviation:  Chem Immunol Allergy     Publication Date:  2006  
Date Detail:
Created Date:  2005-12-15     Completed Date:  2006-03-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101183835     Medline TA:  Chem Immunol Allergy     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  87-97     Citation Subset:  IM    
Almirall Prodesfarma Research Center, Barcelona, Spain.
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MeSH Terms
Acute Disease
Cell Movement
Hypersensitivity / immunology*,  pathology*
Inflammation / immunology,  pathology
Skin Diseases / immunology*,  pathology*
T-Lymphocytes / cytology*,  immunology*

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