| Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease. | |
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MedLine Citation:
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PMID: 23039882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Changes in phenotype and function of γδ T cells have been reported in inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Dysregulation of lymphocyte migration plays a key role in IBD pathogenesis; however, data on migratory properties of γδ T cells are scarce. Human circulating γδ T cells from healthy controls (n = 27), patients with active CD (n = 15), active UC (n = 14) or cutaneous manifestations of IBD (n = 2) were characterized by flow cytometry. Circulating γδ T cells in healthy controls were CD3(hi) and expressed CD45RO. They expressed gut-homing molecule β7 but not gut-homing molecule corresponding chemokine receptors (CCR)9, or skin-homing molecules cutaneous lymphocyte-associated antigen (CLA) and CCR4, despite conventional T cells containing populations expressing these molecules. CCR9 expression was increased on γδ T cells in CD and UC, while skin-homing CLA was expressed aberrantly on γδ T cells in patients with cutaneous manifestations of IBD. Lower levels of CD3 expression were found on γδ T cells in CD but not in UC, and a lower proportion of γδ T cells expressed CD45RO in CD and UC. Enhanced expression of gut-homing molecules on circulating γδ T cells in IBD and skin-homing molecules in cutaneous manifestations of IBD may be of clinical relevance. |
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Authors:
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E R Mann; N E McCarthy; S T C Peake; A N Milestone; H O Al-Hassi; D Bernardo; C T Tee; J Landy; M C Pitcher; S A Cochrane; A L Hart; A J Stagg; S C Knight |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 170 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-08 Completed Date: 2013-03-18 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 122-30 Citation Subset: IM |
Copyright Information:
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© 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. |
Affiliation:
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Antigen Presentation Research Group, Imperial College London, Northwick Park and St Mark’s Campus, Level 7W, St Mark’s Hospital,Watford Road, Harrow HA1 3UJ, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD3 / immunology, metabolism Antigens, CD45 / immunology, metabolism Antigens, Differentiation, T-Lymphocyte / immunology, metabolism Colitis, Ulcerative / immunology, metabolism Crohn Disease / immunology, metabolism* Female Gastrointestinal Tract / immunology*, metabolism Humans Inflammatory Bowel Diseases / immunology*, metabolism Integrin beta Chains / immunology, metabolism Male Membrane Glycoproteins / immunology, metabolism Receptors, CCR / immunology, metabolism Receptors, CCR4 / immunology, metabolism Skin / immunology*, metabolism T-Lymphocyte Subsets / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD3; 0/Antigens, Differentiation, T-Lymphocyte; 0/CC chemokine receptor 9; 0/CCR4 protein, human; 0/CTAGE1 protein, human; 0/Integrin beta Chains; 0/Membrane Glycoproteins; 0/Receptors, CCR; 0/Receptors, CCR4; 0/integrin beta7; EC 3.1.3.48/Antigens, CD45 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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