Document Detail

Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report.
MedLine Citation:
PMID:  20931926     Owner:  NLM     Status:  MEDLINE    
Antibiotic and non-antibiotic sulphonamides are often prescribed. Although chemical differences make cross-reactivity rare, reactions may be severe in patients allergic to sulphur. Adverse reactions are common with sulphonamides but low platelets and skin changes are rarely associated with eye-drops for glaucoma. A woman treated with dorzolamide and timolol presented with disseminated eruption. On admission, her physical examination was unremarkable except for the skin changes and severe thrombocytopaenia was detected. Skin biopsy showed hyperkeratosis, acanthosis, perivascular and periadnexal infiltrates with no vasculitis. After discontinuation of eye-drops, the eruption improved but low platelets persisted. Skin changes reappeared with use of dapsone which suggested sulphonamide cross-reactivity.
V M Santos; R A Castro; C C Lima; M B Moraes; T A M Sugai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The West Indian medical journal     Volume:  59     ISSN:  0043-3144     ISO Abbreviation:  West Indian Med J     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417410     Medline TA:  West Indian Med J     Country:  Jamaica    
Other Details:
Languages:  eng     Pagination:  102-5     Citation Subset:  IM    
School of Medicine, Catholic University of Brasilia and Department of Internal Medicine, Armed Forces Hospital (HFA), Brasilia-DF, Brazil.
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MeSH Terms
Anti-Infective Agents / administration & dosage,  adverse effects*
Antihypertensive Agents / administration & dosage,  adverse effects*
Dapsone / administration & dosage,  adverse effects*
Drug Eruptions*
Glaucoma / drug therapy*
Liver Function Tests
Middle Aged
Ophthalmic Solutions / adverse effects*
Platelet Count
Sulfonamides / administration & dosage,  adverse effects*
Thiophenes / administration & dosage,  adverse effects*
Thrombocytopenia / chemically induced*
Timolol / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antihypertensive Agents; 0/Ophthalmic Solutions; 0/Sulfonamides; 0/Thiophenes; 130693-82-2/dorzolamide; 26839-75-8/Timolol; 80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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