Document Detail

Skin disinfection with octenidine dihydrochloride for central venous catheter site care: a double-blind, randomized, controlled trial.
MedLine Citation:
PMID:  19686276     Owner:  NLM     Status:  MEDLINE    
To compare the efficacy of two commercially available, alcohol-based antiseptic solutions for preparation and care of central venous catheter (CVC) insertion sites, with and without octenidine dihydrochloride, a double-blind, randomized, controlled trial was undertaken in the haematology units and in one surgical unit of two university hospitals. Adult patients with a non-tunnelled CVC were randomly assigned to two different skin disinfection regimens at the insertion site: 0.1% octenidine with 30% 1-propanol and 45% 2-propanol, and as control 74% ethanol with 10% 2-propanol. Endpoints were (i) skin colonization at the insertion site; (ii) positive culture from the catheter tip (> or = 15 CFU); and (iii) occurrence of CVC-associated bloodstream infection (defined according to criteria set by the CDC). Four hundred patients with inserted CVC were enrolled from May 2002 through April 2005. Both groups were similar in respect of patient characteristics and co-morbidities. Skin colonization at the CVC insertion site during the first 10 days was significantly reduced by octenidine treatment (relative difference octenidine vs. control: 0.21; 95%CI: 0.11-0.39, p <0.0001). Positive culture of the catheter tip was significantly less frequent in the octenidine group (7.9%) than in the control group (17.8%): OR = 0.39 (95%CI: 0.20-0.80, p 0.009). Patients treated with octenidine had a non-significant reduction in catheter-associated bloodstream infections (4.1% vs. 8.3%; OR = 0.44; 95%CI: 0.18-1.08, p 0.081). Side effects were similar in both groups. This randomized controlled trial supports the results of two observational studies demonstrating octenidine in alcoholic solution to be a better option than alcohol alone for the prevention of CVC-associated infections.
M Dettenkofer; C Wilson; A Gratwohl; C Schmoor; H Bertz; R Frei; D Heim; D Luft; S Schulz; A F Widmer
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-08-17
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  16     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  600-6     Citation Subset:  IM    
Division of Infection Control and Hospital Epidemiology, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany.
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MeSH Terms
2-Propanol / therapeutic use
Anti-Infective Agents, Local / therapeutic use*
Bacteremia / prevention & control
Catheter-Related Infections / prevention & control*
Catheterization, Central Venous / adverse effects
Catheters / microbiology
Disinfection / methods*
Double-Blind Method
Ethanol / therapeutic use
Hospitals, University
Middle Aged
Pyridines / therapeutic use*
Skin / microbiology*
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Pyridines; 64-17-5/Ethanol; 67-63-0/2-Propanol; 71251-02-0/octenidine

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