| Skin diseases and the dry eye. | |
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MedLine Citation:
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PMID: 3898479 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with oral cicatricial pemphigoid, who present to an oral medicine department, should be examined by an ophthalmologist because over 65 per cent have been found to have an asymptomatic cicatrising conjunctivitis. Early detection and treatment of these patients may help to slow down the scarring process that eventually leads to a dry eye and blindness. The same is true for a group of patients who present to the dermatologist with a non-scarring bullous dermatosis distinguished by the presence of a linear deposit of IgA along the dermo-epidermal junction of uninvolved skin examined by direct immunofluorescence. The cicatrising conjunctivitis found in about 50 per cent of adults with this condition is indistinguishable from that of cicatricial pemphigoid. Ten per cent of patients with cicatricial pemphigoid affecting mucous membranes alone were found to have linear deposits of IgA along the dermo-epidermal junction of uninvolved skin. This suggested that there may be a common pathogenic pathway with varying clinical expression in these groups of patients and presents new possibilities for therapy in some patients with cicatricial pemphigoid. |
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Authors:
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J N Leonard; P Wright; G P Haffenden; D M Williams; C E Griffiths; L Fry |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transactions of the ophthalmological societies of the United Kingdom Volume: 104 ( Pt 4) ISSN: 0078-5334 ISO Abbreviation: Trans Ophthalmol Soc U K Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-11 Completed Date: 1985-10-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0200570 Medline TA: Trans Ophthalmol Soc U K Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 467-76 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Conjunctivitis / complications Dermatitis Herpetiformis / diagnosis Esophagus / radiography Female Fluorescent Antibody Technique Humans Immunoglobulin A / analysis Immunoglobulins / analysis Middle Aged Pemphigoid, Benign Mucous Membrane / complications*, diagnosis, immunology Skin / immunology Skin Diseases, Vesiculobullous / complications*, diagnosis Stomatitis, Aphthous / complications Xerophthalmia / complications* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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