| Skin delivery of oestradiol from lipid vesicles: importance of liposome structure. | |
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MedLine Citation:
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PMID: 11012000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the importance of liposome structure in oestradiol skin delivery as a tool for understanding the delivery mechanism from lipid vesicles. Liposomes of phosphatidylcholine (PC) (1), PC, sodium cholate; 86:14 w/w (II), PC, Span 80; 86.7:13.3 w/w (III) and PC, oleic acid: 84:16 w/w (IV) with 1 mg/ml radiolabelled drug were prepared. Saturated radiolabelled oestradiol solutions containing the components of I-IV were separately prepared in 90% w/w propylene glycol in water. In addition, saturated solutions containing cholate, Span, oleic acid and ethanol at the same concentrations used in vesicles were formulated. Oestradiol permeation through human epidermis was studied. Formulations I-IV increased oestradiol flux by 8.6, 17, 17 and 13-fold when used as vesicles compared with control and by 2.9. 4.0, 4.7 and 6.9-fold when used in solution with drug. Testing individual components in solution, relative fluxes were 2.9, 0.87, 1.1, 2.9 and 1.1 for PC, cholate. Span, oleic acid and 7% ethanol, respectively. Accordingly, it is important to prepare phospholipids as vesicles for efficient oestradiol skin delivery even after inclusion of oleic acid. Penetration enhancement is not the main mechanism for improved flux. Liposome components in solution have additive effect with a possible synergism in some cases. |
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Authors:
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G M El Maghraby; A C Williams; B W Barry |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 204 ISSN: 0378-5173 ISO Abbreviation: Int J Pharm Publication Date: 2000 Aug |
Date Detail:
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Created Date: 2001-01-09 Completed Date: 2001-01-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 159-69 Citation Subset: IM |
Affiliation:
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Drug Delivery Group, Postgraduate Studies in Pharmaceutical Technology, The School of Pharmacy, University of Bradford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chemistry, Pharmaceutical Epidermis / metabolism* Estradiol / pharmacokinetics* Female Humans Liposomes Male Middle Aged Skin Absorption / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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