Document Detail


Skin decontamination of glyphosate from human skin in vitro.
MedLine Citation:
PMID:  18407393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared three model decontaminant solutions (tap water, isotonic saline, and hypertonic saline) for their ability to remove a model herbicide (glyphosate) from an in vitro human skin model. Human cadaver skin was dosed (approximately 375microg) of [14C]-glyphosate on 3cm2 per skin. After each exposure time (1, 3, and 30min post-dosing, respectively), the surface skin was washed three times (4ml per time) with each solution. After washing, the skin was stripped twice with tape discs. Lastly, the wash solutions, strippings, receptor fluid, and remainder of skin were liquid scintillation analyzer counted to determine the amount of glyphosate. There were no statistical differences among these groups at any time points. The total mass balance recovery at three time exposure points was between 94.8% and 102.4%. The wash off rates (glyphosate in wash solutions) at three different exposure times is 79-101.2%. Thus the three tested decontaminants possess similar effectiveness in removing glyphosate from skin. This in vitro model is not only economic and rapid, but also provides quantitative data that may aid screening for optimal decontaminants.
Authors:
H Zhai; H P Chan; X Hui; H I Maibach
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Publication Detail:
Type:  In Vitro; Journal Article     Date:  2008-03-07
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2258-60     Citation Subset:  IM    
Affiliation:
Department of Dermatology, University of California, School of Medicine, Box 0989, Surge 110, 90 Medical Center Way, San Francisco, CA 94143-0989, USA. zhaih@derm.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Decontamination / methods*
Glycine / analogs & derivatives*,  analysis,  pharmacokinetics
Herbicides / analysis*,  pharmacokinetics
Humans
Hypertonic Solutions
Osmotic Pressure
Skin / chemistry*,  metabolism
Skin Absorption
Chemical
Reg. No./Substance:
0/Herbicides; 0/Hypertonic Solutions; 1071-83-6/glyphosate; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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