Document Detail

Skin changes in menopause.
MedLine Citation:
PMID:  2693917     Owner:  NLM     Status:  MEDLINE    
Skin signs and symptoms were examined in 46 menopausal women prior to estrogen replacement therapy. Several symptoms such as pruritus, bruising, dryness and thinning were seen more frequently in sun-exposed skin emphasizing the contribution of photoaging. At the end of a 6-mth treatment period, no significant difference was observed in the prevalence or severity of the cutaneous signs and symptoms when patients receiving transdermal 17 beta-estradiol (Estraderm) were compared with controls (the only exception was cutaneous flushing). Elastic fibers from sun-protected (buttock) skin of menopausal women were studied by light and electron microscopy. In 3 women (ages 30-37) with a history of premature menopause, the elastic fibers had several degenerative changes including coalescence of cystic spaces into lacunae, peripheral fragmentation, granular degeneration and splitting of the fibers into strands. Similar age-related ultrastructural changes are normally found in individuals that are at least 20 yrs older than these patients. These findings are suggestive of a relationship between premature aging of the dermal elastic fibers and estrogen deprivation.
J L Bolognia; I M Braverman; M E Rousseau; P M Sarrel
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Maturitas     Volume:  11     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-07     Completed Date:  1990-03-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  295-304     Citation Subset:  IM    
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut.
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Drug Therapy, Combination
Elastic Tissue / anatomy & histology,  physiology*
Estradiol / blood,  therapeutic use*
Estrogen Replacement Therapy*
Medroxyprogesterone / therapeutic use
Menopause / blood,  physiology*
Microscopy, Electron
Middle Aged
Sebum / physiology
Skin / anatomy & histology
Skin Aging / drug effects
Skin Physiological Phenomena*
Grant Support
Reg. No./Substance:
50-28-2/Estradiol; 520-85-4/Medroxyprogesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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