Document Detail


Skin capillary reperfusion after regional ischemia.
MedLine Citation:
PMID:  2060994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Capillary reperfusion following four hours of regional ischemia was determined in the ear skin microvasculature of 10 homozygous hairless mice. Selective arteriolar ligation was used to produce flow stasis in capillaries within an ischemic risk zone (RSK) without direct compression of the microvasculature under study. Reperfusion capillary RBC velocities (CBV), diameters, and flow times in both RSK and nonischemic capillaries (NRSK) were measured and compared to baseline values after flow stasis was verified in the RSK capillaries. Baseline values of CBV, diameter and flow time did not differ between RSK and NRSK. In the RSK capillaries, the post-ischemic mean CBV was significantly less than baseline (120 +/- 22 vs. 212 +/- 31 microns/s, p less than 0.01), whereas in NRSK capillaries no differences were detected (195 +/- 41 vs. 174 +/- 22 microns/s). The decrease in mean CBV in RSK capillaries was mainly due to an increase in the number of capillaries with low or zero reflow. The percentage of capillaries having CBV less than 100 microns/s increased from 10% at baseline to 45% after ischemia. These results indicate that when capillary flow stasis is produced, durations of skin ischemia of four hours may subject the microvasculature to significant reperfusion deficits.
Authors:
E A Sorrentino; H N Mayrovitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  10     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-08-07     Completed Date:  1991-08-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  105-15     Citation Subset:  IM    
Affiliation:
Miami Heart Institute, FL.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillaries / physiology
Ischemia / physiopathology*
Male
Mice
Mice, Hairless
Reperfusion
Skin / blood supply*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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