| Skin-blanching is associated with FEV(1), allergy, age and gender in asthma families. | |
| | |
MedLine Citation:
|
PMID: 22749754 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Inhaled glucocorticosteroids reduce airway inflammation in asthma patients, thereby improving lung function and reducing airway hyperresponsiveness and symptoms. The response to glucocorticosteroids can be measured with the glucocorticosteroid skin-blanching test. We investigated if asthmatics have a lower skin-blanching response to glucocorticosteroids than non-asthmatic subjects and if asthmatics with airway obstruction have lower skin-blanching response than those without obstruction. Finally, we assessed which clinical and inflammatory parameters influence the variability in skin-blanching response. METHODS: We evaluated the skin-blanching response to topical budesonide in a large group of 315 well-characterized asthmatics and their relatives (asthma n = 114, healthy n = 140, other = 61) RESULTS: The skin-blanching scores of the asthma probands and their healthy spouses were not significantly different. The skin-blanching score of patients with FEV(1) < 80% predicted was lower than of patients without obstruction. Lower skin-blanching score was significantly associated with lower FEV(1) %predicted, higher age, female gender, absence of allergy and summer season, but not with use of inhaled or oral glucocorticosteroids or packyears smoking. CONCLUSIONS: Asthmatics do not have lower skin-blanching response to glucocorticosteroids than healthy subjects. Furthermore, lower skin-blanching response to glucocorticosteroids is associated with lower FEV(1), female gender, higher age and the absence of allergy. |
| | |
Authors:
|
Eef D Telenga; Maarten van den Berge; Judith M Vonk; Hajo Jongepier; Leslie A Lange; Dirkje S Postma; Gerard H Koppelman |
Related Documents
:
|
8381594 - Age-related impairment of k(+)- and acth-stimulated aldosterone secretion by rat adrena... 3393734 - A comparative study of the effects of aging on the responsiveness of the cholinergic re... 3359214 - Ultrastructural alterations in caudate nucleus in aged cats. 1922944 - Longitudinal study on age-related changes of working and reference memory in the rat. 22617094 - 75 years of mortality in the united states, 1935-2010. 423284 - Decelerating the aging process. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-29 |
Journal Detail:
|
Title: Respiratory medicine Volume: - ISSN: 1532-3064 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-7-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8908438 Medline TA: Respir Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
|
Department of Pulmonology, Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On the crest of a wave: Danish prevalence of hospitalisation-required COPD 2002-2009.
Next Document: Asynchronies and sleep disruption in neuromuscular patients under home noninvasive ventilation.