Document Detail

Skin biopsy as a nondestructive tool for the toxicological assessment of endangered populations of pinnipeds: preliminary results on mixed function oxidase in Otaria flavescens.
MedLine Citation:
PMID:  9353903     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to develop and validate a method for assessing the toxicological risk of endangered populations of pinnipeds based on a nondestructive biological tool, the skin biopsy specimen. Skin biopsies can be obtained from pinnipeds by anaesthetising the animals and taking a small amount of skin in the anterior flipper area, or by shooting a biopsy dart with a crossbow. Skin biopsy material is suitable for a wide range of chemical and biomarker analysis. Organochlorines and polycyclic aromatic hydrocarbons can be analysed in subcutaneous fat and MFO activity (BPMO), Cyt.P450 isoforms, and DNA damage can be detected in epidermis.
M C Fossi; C Savelli; L Marsili; S Casini; B Jimenez; M Junin; H Castello; J A Lorenzani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemosphere     Volume:  35     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-04     Completed Date:  1997-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1623-35     Citation Subset:  IM    
Department of Environmental Biology, University of Siena, Italy.
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MeSH Terms
Biological Markers / analysis
Cytochrome P-450 Enzyme System / analysis
Environmental Exposure
Isoenzymes / analysis
Microsomes, Liver / enzymology*,  metabolism
Mixed Function Oxygenases / analysis*,  metabolism
Pesticide Residues / analysis
Pinnipedia / metabolism*
Polycyclic Hydrocarbons, Aromatic / analysis*,  metabolism
Seals, Earless / metabolism*
Seawater / chemistry
Skin / enzymology*,  pathology
Toxicity Tests
Water Pollutants, Chemical / analysis*
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; 0/Pesticide Residues; 0/Polycyclic Hydrocarbons, Aromatic; 0/Water Pollutants, Chemical; 9035-51-2/Cytochrome P-450 Enzyme System; EC 1.-/Mixed Function Oxygenases

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