Document Detail


Skin as the site of vitamin D synthesis and target tissue for 1,25-dihydroxyvitamin D3. Use of calcitriol (1,25-dihydroxyvitamin D3) for treatment of psoriasis.
MedLine Citation:
PMID:  2825606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D is a hormone, not a vitamin. The skin is responsible for producing vitamin D. During exposure to sunlight, ultraviolet radiation penetrates into the epidermis and photolyzes provitamin D3 to previtamin D3. Previtamin D3 can either isomerize to vitamin D3 or be photolyzed to lymisterol and tachysterol. Vitamin D is also sensitive to sunlight and is photolyzed to 5,6-transvitamin D3, suprasterol I, and suprasterol II. In Boston, solar irradiation only produces previtamin D3 in the skin between the months of March and October. Aging, sunscreens, and melanin all diminish the capacity of the skin to produce previtamin D3. Once formed, vitamin D3 enters the circulation and is sequentially metabolized to 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 (1,25-[OH]2-D3). The epidermis possesses receptors for 1,25-(OH)2-D3. 1,25-(OH)2-D3 inhibits the proliferation of cultured keratinocytes and induces them to terminally differentiate. The topical or oral administration of 1,25-(OH)2-D3 has proved to be effective for the treatment of psoriasis. Therefore, the skin is the site for the synthesis of vitamin D and a target tissue for its active metabolite. The successful use of 1,25-(OH)2-D3 for the treatment of psoriasis heralds a new approach for the treatment of this enigmatic disorder.
Authors:
M F Holick; E Smith; S Pincus
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Archives of dermatology     Volume:  123     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1987-12-31     Completed Date:  1987-12-31     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1677-1683a     Citation Subset:  AIM; IM    
Affiliation:
US Department of Agriculture/Human Nutrition Research Center, Tufts University, Boston, MA.
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MeSH Terms
Descriptor/Qualifier:
Calcitriol / metabolism,  therapeutic use*
Cells, Cultured
Cholecalciferol / biosynthesis
Humans
Photosynthesis
Psoriasis / drug therapy*
Skin / drug effects,  metabolism*
Vitamin D / biosynthesis*
Chemical
Reg. No./Substance:
1173-13-3/previtamin D(3); 1406-16-2/Vitamin D; 32222-06-3/Calcitriol; 67-97-0/Cholecalciferol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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