Document Detail


Skin as a potential source of infectious foot and mouth disease aerosols.
MedLine Citation:
PMID:  21450741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review examines whether exfoliated, virus-infected animal skin cells could be an important source of infectious foot and mouth disease virus (FMDV) aerosols. Infectious material rafting on skin cell aerosols is an established means of transmitting other diseases. The evidence for a similar mechanism for FMDV is: (i) FMDV is trophic for animal skin and FMDV epidermis titres are high, even in macroscopically normal skin; (ii) estimates for FMDV skin cell aerosol emissions appear consistent with measured aerosol emission rates and are orders of magnitude larger than the minimum infectious dose; (iii) the timing of infectious FMDV aerosol emissions is consistent with the timing of high FMDV skin concentrations; (iv) measured FMDV aerosol sizes are consistent with skin cell aerosols; and (v) FMDV stability in natural aerosols is consistent with that expected for skin cell aerosols. While these findings support the hypothesis, this review is insufficient, in and of itself, to prove the hypothesis and specific follow-on experiments are proposed. If this hypothesis is validated, (i) new FMDV detection, management and decontamination approaches could be developed and (ii) the relevance of skin cells to the spread of viral disease may need to be reassessed as skin cells may protect viruses against otherwise adverse environmental conditions.
Authors:
Michael B Dillon
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-03-30
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  278     ISSN:  1471-2954     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-08-26     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1761-9     Citation Subset:  IM    
Affiliation:
Lawrence Livermore National Laboratory, PO Box 808, L-103, Livermore, CA 94551, USA. dillon7@llnl.gov
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MeSH Terms
Descriptor/Qualifier:
Aerosols*
Animals
Foot-and-Mouth Disease / transmission*
Foot-and-Mouth Disease Virus / physiology*
Livestock / virology*
Skin / cytology,  virology*
Virus Shedding
Chemical
Reg. No./Substance:
0/Aerosols
Comments/Corrections

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