Document Detail

Skin anti-inflammatory activity of apigenin-7-glucoside in rats.
MedLine Citation:
PMID:  7683883     Owner:  NLM     Status:  MEDLINE    
The effect of apigenin-7-glucoside on skin inflammation induced by different generators of reactive oxygen species and free radicals was studied. Skin inflammation in rats was induced by intradermal injection of glucose-oxidase (hydrogen peroxide), xanthine-oxidase/hypoxanthine (superoxide anion radical), and cumene hydroperoxide (peroxyl radical). Subsequent intradermal application of liposomal apigenin-7-glucoside inhibited in a dose dependent manner skin inflammation caused by xanthine-oxidase and cumene hydroperoxide. Glucose-oxidase induced dermatitis was not significantly inhibited. The results are in good agreement with the in-vitro superoxide anion radical and peroxyl radical scavenging properties of apigenin and indicate that its antioxidant properties contribute to the anti-inflammatory effect in this model system.
J Fuchs; R Milbradt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  43     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-06-04     Completed Date:  1993-06-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  370-2     Citation Subset:  IM    
Abteilung II, Klinikum der Johann Wolfgang Goethe Universität, Frankfurt/Main, Fed. Rep. of Germany.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*,  therapeutic use
Antioxidants / pharmacology
Benzene Derivatives / pharmacology
Dermatitis, Contact / drug therapy*,  metabolism,  pathology
Flavonoids / pharmacology*
Glucose Oxidase / pharmacology
Histamine Release / drug effects
Prostaglandins / biosynthesis
Rats, Wistar
Xanthine Oxidase / pharmacology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antioxidants; 0/Benzene Derivatives; 0/Flavonoids; 0/Liposomes; 0/Prostaglandins; 520-36-5/Apigenin; 578-74-5/apigetrin; 80-15-9/cumene hydroperoxide; EC Oxidase; EC Oxidase

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