Document Detail

Skin-resident T cells: the ups and downs of on site immunity.
MedLine Citation:
PMID:  19675575     Owner:  NLM     Status:  MEDLINE    
The cutaneous surface of a normal adult individual contains approximately 20 billion T cells, nearly twice the number present in the entire circulation. Recent studies have shown a role for these cells in both normal immunity and in inflammatory skin diseases such as psoriasis. Regulatory T cells protect against autoimmune reactions to self antigens and assist in the resolution of cutaneous inflammation. However, they can also shield tumors from immune detection, allow latent infections to persist and can dysfunction under the conditions present in inflammatory skin diseases. Th17 T cells protect organisms against extracellular pathogens but also have a key role in the pathogenesis of psoriasis. Evidence suggests that effector memory T cells produced during immune reactions survive and persist long term within the skin, providing local and rapid protection against pathogen reexposure. This review summarizes the current understanding of how skin-resident T cells contribute to normal and aberrant immunity in the skin.
Rachael A Clark
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-08-13
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  130     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-02-18     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-70     Citation Subset:  IM    
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MeSH Terms
Immune System
Immunologic Memory
Interleukin-17 / chemistry
Models, Biological
Psoriasis / immunology
Skin / metabolism*,  pathology
Skin Physiological Phenomena
T-Lymphocyte Subsets / immunology
T-Lymphocytes / metabolism*
Grant Support
1K08AI060890-01A1/AI/NIAID NIH HHS; 1R01AR056720-01A1/AR/NIAMS NIH HHS; 1R01CA122569-01A/CA/NCI NIH HHS; K08 AI060890/AI/NIAID NIH HHS; K08 AI060890-04/AI/NIAID NIH HHS; R01 AR056720/AR/NIAMS NIH HHS; R01 AR056720-02/AR/NIAMS NIH HHS
Reg. No./Substance:

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