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Skin Of Patients With Large/Giant Congenital Melanocytic Nevi Shows Increased Mast Cells.
MedLine Citation:
PMID:  24679055     Owner:  NLM     Status:  Publisher    
Abstract Nevocytes (NC) and mastocytes (MC) have different progenitors but share stem-cell factor as regulator/activator of NC, and for differentiation/proliferation of MC. Both cell types express SCF receptor CD117. We hypothesize that Large/Giant Congenital Mela-nocytic Nevi (L/GCMN) may associate with MC hyperplasia. Design: 49 L/GCMN, 12 samples from uninvolved skin of L/GCMN patients and 6 con-trol skin samples studied with Giemsa, and immunohistochemistry for CD117 and MC-tryptase. Picrosirius red (PR) was used to assess fibrosis. Digital images were used to count MC/mm2 using ImageJ® software. Western blot (WB) for MC-tryptase in 12 GCMN and 12 non-nevus samples was performed. ANOVA (Tukey) and Pierson statis-tical tests were applied. Results: Increased MCs were observed in nevus tissue (75.1 ± 35.3 MCs/mm2) and in uninvolved skin (53.74 ± 27.7 MC/ mm2) p=0.109 from patients with L/GCMN, compared with controls from individuals without L/GCMN (28.74 ± 8.4 MC/mm2); p=0.001, sup-ported by results of WB analysis for tryptase. A positive trend toward correlation of MC numbers with fibrosis, assessed by PR staining fell short of statistical significance (r= 0.245; p=0.086); no difference in fibrosis was found between nevus and non-nevus skin from patients with L/GCMN (p=0.136). Conclusions: We found a higher density of MC, both in normal-appearing skin and ne-vus areas of L/GCMN patients, compared with control skin samples from individuals without nevi. Given the abnormal wound healing and allergic reactions described in L/GCMN patients, these findings suggest a potential role for MC in the biology of L/GCMN, making them a potential target for therapeutic intervention.
Cláudia M Salgado; Randi B Silver; Bruce S Bauer; Dipanjan Basu; Lori A Schmitt; Yasmin Khakoo; Miguel Reyes-Múgica
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-28
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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