Document Detail

Skin ceramide alterations in first-episode schizophrenia indicate abnormal sphingolipid metabolism.
MedLine Citation:
PMID:  22589371     Owner:  NLM     Status:  MEDLINE    
There is considerable evidence for specific pathology of lipid metabolism in schizophrenia, affecting polyunsaturated fatty acids and in particular sphingolipids. These deficits are assumed to interfere with neuronal membrane functioning and the development and maintenance of myelin sheaths. Recent studies suggest that some of these lipid pathologies might also be detected in peripheral skin tests. In this study, we examined different skin lipids and their relation to schizophrenia. We assessed epidermal lipid profiles in 22 first-episode antipsychotic-naïve schizophrenia patients and 22 healthy controls matched for age and gender using a hexan/ethanol extraction technique and combined high-performance thin-layer chromatography/gas-chromatography. We found highly significant increase of ceramide AH and NH/AS classes in patients and decrease of EOS and NP ceramide classes. This is the first demonstration of specific peripheral sphingolipid alterations in schizophrenia. The results support recent models of systemic lipid pathology and in particular of specific sphingolipids, which are crucial in neuronal membrane integrity. Given recent findings showing amelioration of psychopathology using fatty acid supplementation, our findings also bear relevance for sphingolipids as potential biomarkers of the disease.
Stefan Smesny; Christian E H Schmelzer; Anke Hinder; Alexandra Köhler; Christiane Schneider; Maria Rudzok; Ulrike Schmidt; Berko Milleit; Christine Milleit; Igor Nenadic; Heinrich Sauer; Reinhard H H Neubert; Joachim W Fluhr
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-15
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  39     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-20     Completed Date:  2014-02-14     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  933-41     Citation Subset:  IM    
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MeSH Terms
Case-Control Studies
Ceramides / metabolism*
Chromatography, High Pressure Liquid
Epidermis / chemistry*
Gas Chromatography-Mass Spectrometry
Myelin Sheath / metabolism
Nerve Fibers, Myelinated / metabolism
Psychotic Disorders / metabolism*
Schizophrenia / metabolism*
Sphingolipids / metabolism*
Young Adult
Reg. No./Substance:
0/Ceramides; 0/Sphingolipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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