Document Detail

Skim soy protein enhances GFR as much as beefsteak protein in healthy human subjects.
MedLine Citation:
PMID:  15235926     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been reported that an acute load of beefsteak (200 g) significantly enhanced the glomerular filtration rate (GFR; inulin clearance and creatinine clearance) in healthy human subjects compared to that in the same subjects in the fasted state. However, no comparative study of the effects of the same amount of vegetable protein on GFR has been reported to date. METHODS: We attempted to compare changes in the GFR (inulin clearance and creatinine clearance) in six healthy male subjects following consumption of the same amount of beefsteak or baked skim soy with soy sauce (protein, 86.9 g) after fasting. The clearance study was performed by conventional methods. Inulin was measured by the anthrone method. Creatinine was measured by the Jaffe rate assay method. Amino-acid analysis of the beefsteak and baked skim soy with soy sauce was done by acid or hydroxide hydrolysis and an amino-acid analyzer. RESULTS: A significant enhancement of the GFR (both inulin clearance and creatinine clearance) was observed following acute loading with beefsteak or baked skim soy with soy sauce, compared to the GFR in the fasted state. No significant difference was observed between the results with beefsteak and the results with baked skim soy with soy sauce. Amino-acid analysis revealed that the total amount of three amino acids (glycine, alanine, and arginine; or serine, alanine, and proline) was almost identical in beefsteak (animal protein) and baked skim soy with soy sauce (vegetable protein). CONCLUSIONS: The present study demonstrated that vegetable protein with the same amino-acid composition could enhance the GFR in healthy subjects as much as animal protein.
Yoshimasa Orita; Masako Okada; Shingo Harada; Masaru Horio
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental nephrology     Volume:  8     ISSN:  1342-1751     ISO Abbreviation:  Clin. Exp. Nephrol.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-05     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709923     Medline TA:  Clin Exp Nephrol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
College of Nutrition Koshien University, 10-1 Momijigaoka, Takarazuka 665-0006, Japan.
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MeSH Terms
Amino Acids / pharmacokinetics
Creatinine / metabolism
Glomerular Filtration Rate / drug effects*
Glucagon / blood
Inulin / diagnostic use
Soybean Proteins / administration & dosage*
Reg. No./Substance:
0/Amino Acids; 0/Soybean Proteins; 60-27-5/Creatinine; 9005-80-5/Inulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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