Document Detail

Skewing towards neuroendocrine phenotype in high grade or high stage androgen-responsive primary prostate cancer.
MedLine Citation:
PMID:  15992991     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration. METHODS: Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies. RESULTS: High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or localized diseases (p < 0.005). Both the CgA score of the surgical specimens and the PSA level in the serum increased linearly (p = 0.001). In the samples of many corresponding tumor biopsies no significant CgA staining was found. CONCLUSION: NE differentiation in primary untreated prostate cancer is closely associated with the major prognostic parameters of survival. This association cannot be shown by evaluating the CgA staining in tumor biopsies.
Luca Puccetti; Claudiu T Supuran; Pier P Fasolo; Enrico Conti; Giancarlo Sebastiani; Sergio Lacquaniti; Roberto Mandras; Maria G Milazzo; Natalia Dogliani; Paolo De Giuli; Giuseppe Fasolis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-02
Journal Detail:
Title:  European urology     Volume:  48     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  215-21; Discussion 221-3     Citation Subset:  IM    
Ospedale San Lazzaro, Divisione di Urologia, Via Pierino Belli 26, 12051 Alba, Cuneo, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Chi-Square Distribution
Chromogranins / metabolism*
Middle Aged
Neurosecretory Systems / pathology
Prostate-Specific Antigen / blood
Prostatic Neoplasms / metabolism*,  pathology*,  surgery
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Chromogranins; 0/Tumor Markers, Biological; EC Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to t...
Next Document:  Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy.