Document Detail


Skewing towards neuroendocrine phenotype in high grade or high stage androgen-responsive primary prostate cancer.
MedLine Citation:
PMID:  15992991     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration. METHODS: Chromogranin A (CgA) expression was scored and compared in 105 consecutive primary prostate cancers with their homologous preoperative tumor prostate biopsies. RESULTS: High grade or high stage prostate cancers expressed a significantly higher CgA score than low grade or localized diseases (p < 0.005). Both the CgA score of the surgical specimens and the PSA level in the serum increased linearly (p = 0.001). In the samples of many corresponding tumor biopsies no significant CgA staining was found. CONCLUSION: NE differentiation in primary untreated prostate cancer is closely associated with the major prognostic parameters of survival. This association cannot be shown by evaluating the CgA staining in tumor biopsies.
Authors:
Luca Puccetti; Claudiu T Supuran; Pier P Fasolo; Enrico Conti; Giancarlo Sebastiani; Sergio Lacquaniti; Roberto Mandras; Maria G Milazzo; Natalia Dogliani; Paolo De Giuli; Giuseppe Fasolis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-02
Journal Detail:
Title:  European urology     Volume:  48     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  215-21; Discussion 221-3     Citation Subset:  IM    
Affiliation:
Ospedale San Lazzaro, Divisione di Urologia, Via Pierino Belli 26, 12051 Alba, Cuneo, Italy. lpuccetti@asl18.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biopsy
Chi-Square Distribution
Chromogranins / metabolism*
Humans
Immunohistochemistry
Male
Middle Aged
Neurosecretory Systems / pathology
Phenotype
Prognosis
Prostate-Specific Antigen / blood
Prostatectomy
Prostatic Neoplasms / metabolism*,  pathology*,  surgery
Tumor Markers, Biological / metabolism
Chemical
Reg. No./Substance:
0/Chromogranins; 0/Tumor Markers, Biological; EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to t...
Next Document:  Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy.