Document Detail


Skewed distribution of natural killer cells in psoriasis skin lesions.
MedLine Citation:
PMID:  23278897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psoriasis is a hyper-proliferative disease of the skin in which immunological mechanisms play a direct pathogenetic role. There have been limited studies of natural killer (NK) cells in psoriasis. The aim of this study was to examine the phenotype of NK cells in skin biopsies and peripheral blood mononuclear cells from patients with psoriasis and healthy controls. CD56(+) CD16(-) and CD56(+) CD16(+) NK cells were isolated from lesional skin, unaffected skin and PBMC of psoriasis patients, and normal skin and PBMC from healthy controls. The expression of CD57, NKG2A and NKG2C was assessed by flow cytometry. NK cells in psoriasis skin lesions were skewed in their expression of CD57, a marker of NK cell maturity, with CD57 expression significantly reduced and NKG2A expression increased on NK cells in lesional and unaffected skin compared to controls. These data suggest that in this patient cohort, NK cells could be isolated from psoriasis lesions and exhibit an immature phenotype.
Authors:
Mariana D Batista; Emily L Ho; Peter J Kuebler; Jeffrey M Milush; Lewis L Lanier; Esper G Kallas; Vanessa A York; David Chang; Wilson Liao; Patrick Unemori; Kieron S Leslie; Toby Maurer; Douglas F Nixon
Related Documents :
24638067 - Btb-zf transcription factors, a growing family of regulators of early and late b-cell d...
23300177 - The pd-1/pd-l1 axis contributes to t cell dysfunction in chronic lymphocytic leukemia.
24056747 - The transcription factor irf4 is essential for tcr affinity-mediated metabolic programm...
25109697 - Epstein-barr virus-associated t-cell lymphoproliferative disorder affecting skin and lu...
8588347 - Cd8+ lymphocytes in bronchoalveolar lavage and blood: in vivo indicators of lung pathol...
16783847 - Pertussis toxin activates adult and neonatal naive human cd4+ t lymphocytes.
Publication Detail:
Type:  Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental dermatology     Volume:  22     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-27     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  64-6     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, CD56 / metabolism
Antigens, CD57 / metabolism*
Cell Differentiation
Humans
Killer Cells, Natural / metabolism*
Male
Middle Aged
NK Cell Lectin-Like Receptor Subfamily C / metabolism
Phenotype
Psoriasis / blood,  immunology*
Receptors, IgG / metabolism
Skin / cytology,  immunology
Young Adult
Grant Support
ID/Acronym/Agency:
5K08AR057763/AR/NIAMS NIH HHS; 5T32HL007185/HL/NHLBI NIH HHS; AI068129/AI/NIAID NIH HHS; AI64520/AI/NIAID NIH HHS; K08 AR057763/AR/NIAMS NIH HHS; P30 DK063720/DK/NIDDK NIH HHS; R01 AI068129/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD56; 0/Antigens, CD57; 0/KLRC1 protein, human; 0/KLRC2 protein, human; 0/NK Cell Lectin-Like Receptor Subfamily C; 0/Receptors, IgG
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spontaneous occurrence of photoageing-like phenotypes in the dorsal skin of old SAMP1 mice, an oxida...
Next Document:  The effects of Sophora angustifolia and other natural plant extracts on melanogenesis and melanin tr...