Document Detail

Skewed X chromosome inactivation may be not associated with premature ovarian failure.
MedLine Citation:
PMID:  20170342     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In view of the controversies about the skewed X chromosome inactivation (XCI) and premature ovarian failure (POF) association, a meta-analysis of the published data was performed to evaluate the relationship between XCI skewing and POF. METHODS: We searched for all published articles indexed in MEDLINE (1950 approximately 2009) and CNKI (1994 approximately 2009). Any case-control or cohort study that tested the association between skewed XCI and POF was included and data were extracted independently by two reviewers. We performed this meta-analysis involving 325 cases and 403 controls with Review Manager 4.2 software. RESULTS: Four eligible studies were selected for meta-analysis. It suggested that there was no significant difference between the incidence of skewed XCI (XCI >or=70% skewing) in POF cases comparing to healthy controls, odds ratio (OR) = 1.13 [95% confidence interval (CI): 0.84 approximately 1.53, P = 0.42]. The link between extremely skewed XCI (XCI >or=90% skewing) and POF was also analysed, and no significant difference was found, either, OR = 1.46 (95% CI: 0.79 approximately 2.69, P = 0.22). CONCLUSIONS: Skewed XCI had no association with POF. However, more case-control and cohort studies are needed in the future.
Danhua Pu; Jie Wu; Jiayin Liu
Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-06     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
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MeSH Terms
Chromosomes, Human, X / genetics*
Middle Aged
Ovarian Failure, Premature / genetics*
X Chromosome Inactivation / genetics*
Young Adult

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