| Skewed X chromosome inactivation may be not associated with premature ovarian failure. | |
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MedLine Citation:
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PMID: 20170342 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In view of the controversies about the skewed X chromosome inactivation (XCI) and premature ovarian failure (POF) association, a meta-analysis of the published data was performed to evaluate the relationship between XCI skewing and POF. METHODS: We searched for all published articles indexed in MEDLINE (1950 approximately 2009) and CNKI (1994 approximately 2009). Any case-control or cohort study that tested the association between skewed XCI and POF was included and data were extracted independently by two reviewers. We performed this meta-analysis involving 325 cases and 403 controls with Review Manager 4.2 software. RESULTS: Four eligible studies were selected for meta-analysis. It suggested that there was no significant difference between the incidence of skewed XCI (XCI >or=70% skewing) in POF cases comparing to healthy controls, odds ratio (OR) = 1.13 [95% confidence interval (CI): 0.84 approximately 1.53, P = 0.42]. The link between extremely skewed XCI (XCI >or=90% skewing) and POF was also analysed, and no significant difference was found, either, OR = 1.46 (95% CI: 0.79 approximately 2.69, P = 0.22). CONCLUSIONS: Skewed XCI had no association with POF. However, more case-control and cohort studies are needed in the future. |
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Authors:
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Danhua Pu; Jie Wu; Jiayin Liu |
Publication Detail:
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Type: Journal Article; Meta-Analysis |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 423-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Chromosomes, Human, X / genetics* Female Humans Middle Aged Ovarian Failure, Premature / genetics* X Chromosome Inactivation / genetics* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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