| Skeletal resistance to pth as a basic abnormality underlying uremic bone diseases. | |
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MedLine Citation:
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PMID: 11576943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal resistance to parathyroid hormone (PTH) was suggested initially as a mechanism of PTH hypersecretion in uremia. Because of the effective suppression of PTH by recently developed therapeutic modalities, this background abnormality has been uncovered and currently recognized as relative hypoparathyroidism in terms of its relation to bone turnover. Thus, PTH levels two to three times greater than normal are usually required to keep bone turnover normal in uremia. Recent studies suggested that PTH activity may be overestimated using the conventional intact PTH assay. In addition, several steps to osteoclastogenesis are suspected to be disturbed in uremia. Additional studies at cellular and molecular levels are needed to establish preventive and therapeutic modalities for this abnormality. |
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Authors:
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M Fukagawa; J J Kazama; T Shigematsu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 38 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-09-28 Completed Date: 2001-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: S152-5 Citation Subset: IM |
Affiliation:
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Division of Nephrology and Dialysis Center, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. fukagawa@med.kobe-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Resorption
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etiology,
metabolism* Bone and Bones / metabolism* Disease Progression Glycoproteins / metabolism Humans Hyperplasia Osteoprotegerin Parathyroid Glands / metabolism, pathology Parathyroid Hormone / metabolism* Receptors, Cytoplasmic and Nuclear / metabolism Receptors, Tumor Necrosis Factor Uremia / complications, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Osteoprotegerin; 0/Parathyroid Hormone; 0/Receptors, Cytoplasmic and Nuclear; 0/Receptors, Tumor Necrosis Factor; 0/TNFRSF11B protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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