| Skeletal muscle reoxygenation after high-intensity exercise in mitochondrial myopathy. | |
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MedLine Citation:
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PMID: 21898145 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study addressed whether O(2) delivery during recovery from high-intensity, supra-gas exchange threshold exercise would be matched to O(2) utilization at the microvascular level in patients with mitochondrial myopathy (MM). Off-exercise kinetics of (1) pulmonary O(2) uptake [Formula: see text] (2) an index of fractional O(2) extraction by near-infrared spectroscopy (Δ[deoxy-Hb + Mb]) in the vastus lateralis and (3) cardiac output (Q (T) (') ) by impedance cardiography were assessed in 12 patients with biopsy-proven MM (chronic progressive external ophthalmoplegia) and 12 age- and gender-matched controls. Kinetics of [Formula: see text] were significantly slower in patients than controls (τ = 53.8 ± 16.5 vs. 38.8 ± 7.6 s, respectively; p < 0.05). Q (T) (') , however, declined at similar rates (τ = 64.7 ± 18.8 vs. 73.0 ± 21.6 s; p > 0.05) being typically slower than [Formula: see text] in both groups. Importantly, Δ[deoxy-Hb + Mb] dynamics (MRT) were equal to, or faster than, [Formula: see text] in patients and controls, respectively. In fact, there were no between-group differences in [Formula: see text]/MRTΔ[deoxy-Hb + Mb] (1.1 ± 0.4 vs. 1.0 ± 0.2, p > 0.05) thereby indicating similar rates of microvascular O(2) delivery. These data indicate that the slower rate of recovery of muscle metabolism after high-intensity exercise is not related to impaired microvascular O(2) delivery in patients with MM. This phenomenon, therefore, seems to reflect the intra-myocyte abnormalities that characterize this patient population. |
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Authors:
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Daniela M Bravo; Ana Cristina Gimenes; Rúbia B Nascimento; Eloara V M Ferreira; Ana Cristina B Siqueira; Ethiane D S Meda; J Alberto Neder; Luiz Eduardo Nery |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-4 |
Journal Detail:
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Title: European journal of applied physiology Volume: - ISSN: 1439-6327 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Respiratory Medicine, Department of Medicine, Pulmonary Function and Clinical Exercise Physiology Unit, Federal University of Sao Paulo, Paulista School of Medicine (UNIFESP-EPM), Rua Botucatu, 740 3rd floor, Vila Clementino, Sao Paulo, Sao Paulo, CEP 04023-062, Brazil, danielamanzoli@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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