| Skeletal muscle regeneration in myopathic hamsters of strain BIO 8262. | |
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MedLine Citation:
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PMID: 821245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Skeletal muscle regeneration was studied in polymyopathic hamsters of the strain BIO 8262 by autoradiography. Flash labeling with 3H-thymidine revealed high labeling indices of mononuclear cells in areas with muscle cell necroses and low labeling of "interstitial cells". However, no labeled nuclei were present in myotubes. Three days after multiple injections of the radioisotope, labeled nuclei in the myotubes were present. The mean labeling intensity of these nuclei was slightly elevated on the 15th day. On the third day after multiple 3H-thymidine injections nearly all mononuclear cells were labeled; but their labeling indices slightly decreased until the 15th day. From the decrease of labeling intensity, a high turnover rate of these cells may be assumed. Labeled myotubes appeared in the neighborhood of mononuclear cells as well as in areas without pronounced round cell infiltrations. From labeled myotubes in areas with round cell infiltrations it may be concluded that they arose by fusion of rapidly proliferating satellite cells, which may be constituents of the mononuclear cell population. Labeled myotubes that appeared outside areas of mononuclear cell infiltrations may have been caused by fusion of slow proliferating satellite cells. Despite the fact of a high regeneration capacity of muscle in hamsters of the strain BIO 8262, this process is not sufficient to completely restore the muscle necroses. |
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Authors:
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W Mohr; G Bock; K Lossnitzer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virchows Archiv. B: Cell pathology Volume: - ISSN: 0340-6075 ISO Abbreviation: Virchows Arch B Cell Pathol Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1976-10-01 Completed Date: 1976-10-01 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0437105 Medline TA: Virchows Arch B Cell Pathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 67-77 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Cricetinae Muscles / physiopathology* Muscular Diseases / physiopathology* Necrosis Regeneration* Thymidine Time Factors Tritium |
| Chemical | |
Reg. No./Substance:
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10028-17-8/Tritium; 50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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