Document Detail

Skeletal muscle perfusion measurements using adiabatic inversion of arterial water.
MedLine Citation:
PMID:  9211378     Owner:  NLM     Status:  MEDLINE    
Quantitative NMR measurements of perfusion using magnetic labeling of arterial water have been demonstrated previously in several different highly perfused organs. The success of these previous experiments suggested that arterial labeling may be of use in measuring perfusion in skeletal muscle, where resting perfusion is very low and where increased perfusion after exercise is transient. In the experiments described in this paper, adiabatic inversion of arterial water has been used to make single-voxel measurements of perfusion in the lower hind limb of rats. At rest, the NMR results were quantified to yield a perfusion rate of about 13.8 ml/100g/min. After perturbation due to ischemic exercise, large relative changes in the NMR signal were observed. The peak change of about 2.5% of the NMR signal occurred shortly after perturbation and was followed by a return to resting levels over a period of about 4 min.
K I Marro; M J Kushmerick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  38     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-09     Completed Date:  1997-09-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-7     Citation Subset:  IM    
Center for Bioengineering, University of Washington, Seattle 98195-7115, USA.
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MeSH Terms
Ischemia / physiopathology
Magnetic Resonance Spectroscopy / methods*
Muscle Contraction
Muscle, Skeletal / blood supply*
Rats, Sprague-Dawley
Regional Blood Flow
Spin Labels
Reg. No./Substance:
0/Spin Labels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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