| Skeletal muscle perfusion during exercise using Gd-DTPA bolus detection. | |
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MedLine Citation:
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PMID: 11545125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The study was performed to evaluate if skeletal muscle perfusion can be determined during exercise using an IV bolus injection of Gd-DTPA. A fast spoiled gradient echo sequence (T1 weighted) was used with intermittent imaging during one-legged plantar flexion at different workloads. Between repetitive flexions, a 2-sec rest allowed magnetic resonance imaging (MRI) of the lower legs and measurements of the blood flow in the popliteal artery by ultrasonography for subsequent calculation of muscle perfusion. Maximal signal intensity, upslope and downslope of the bolus, mean transit time, and integrated curve area were measured within regions of interest bilaterally. The skeletal muscle perfusion estimated by ultrasonography increased in the exercising leg from 4 ml x 100 g(-1) x min(-1) at rest to 38 ml at low, 86 ml at medium, and 110 ml x 100 g(-1) x min(-1) at high workload. The SImax increased from 1.38 +/- 0.12 to 1.58 +/- 0.15 and the negative slope of the peak nonsignificantly from - 2.38 +/- 1.75 to - 12.05 +/- 9. 71. All obtained MRI parameters could visually separate the muscles into exercising, nonexercising, and presumably low active muscles. It is concluded that the signal intensity curve using a fast spoiled gradient echo sequence did not overall quantitatively mirror the perfusion, evaluated as the blood flow measured by ultrasonography. However, the signal intensity seemed to follow the blood flow velocity within a limited range of 15-60 cm x sec(-1), corresponding to 35-90 ml x 100 g(-1) x min(-1). Nonetheless, it might be useful when studying ischemia or endothelial dysfunction in skeletal muscles during exercise. |
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Authors:
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A T Nygren; D Greitz; L Kaijser |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance Volume: 2 ISSN: 1097-6647 ISO Abbreviation: J Cardiovasc Magn Reson Publication Date: 2000 |
Date Detail:
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Created Date: 2001-09-06 Completed Date: 2001-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9815616 Medline TA: J Cardiovasc Magn Reson Country: United States |
Other Details:
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Languages: eng Pagination: 263-70 Citation Subset: IM |
Affiliation:
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Department of Medical Laboratory Sciences & Technology, Huddinge University Hospital, Karolinska Institutet, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / physiology Contrast Media* Exercise / physiology* Female Gadolinium DTPA / diagnostic use* Humans Image Enhancement* Isometric Contraction / physiology Magnetic Resonance Imaging* Male Muscle, Skeletal / blood supply* Reference Values Regional Blood Flow / physiology Ultrasonography, Doppler, Duplex Weight-Bearing / physiology |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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