Document Detail


Skeletal muscle oxygenation and oxygen uptake kinetics following constant work rate exercise in chronic congestive heart failure.
MedLine Citation:
PMID:  9388106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to determine the kinetics of recovery of muscle oxygenation (MO) from comparable levels of exercise in patients with chronic congestive heart failure (CHF) and in normal subjects, and to relate MO kinetics to the level of exercise intolerance. Ten patients with stable CHF secondary to ischemic cardiomyopathy (ejection fraction 34 +/- 6%) (mean age 47 +/- 10 years) and 8 healthy matched control subjects underwent an upright incremental cycle ergometer exercise test with gas exchange analysis and a 6-minute constant work rate protocol at 60% of peak oxygen consumption (VO2). Oxygenation of the vastus lateralis muscle was continuously monitored during exercise and recovery using near infrared spectroscopy. Recovery VO2 and MO mean response times for the constant work rate exercise test were longer in patients with CHF than in control subjects (p <0.05). Both VO2 and MO mean response times were inversely related to peak VO2 (r = -0.73 and -0.52, respectively; p <0.05 for both). Thus recovery of muscle and total body oxygenation from submaximal exercise is more delayed the greater the cardiac dysfunction, as assessed by peak VO2. This suggests that regeneration of phosphocreatine and/or resaturation of venous oxyhemoglobin take place more slowly the worse the cardiac function.
Authors:
R Belardinelli; T J Barstow; P Nguyen; K Wasserman
Related Documents :
9223536 - The cardiac effects of pimobendan (but not amrinone) are preserved at rest and during e...
7781336 - Neurohormonal activation and exercise function in patients with severe heart failure an...
16449866 - Effects of exercise rehabilitation program on heart rate recovery in patients with chro...
18255336 - Prognostic value and diagnostic potential of cardiopulmonary exercise testing in patien...
2383816 - Postexercise proteinuria in rowers.
24528106 - Water intake, faecal output and intestinal motility in horses moved from pasture to a s...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  80     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-09     Completed Date:  1997-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1319-24     Citation Subset:  AIM; IM; S    
Affiliation:
Department of Medicine, Harbor-UCLA Medical Center, Torrance, California, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Chronic Disease
Exercise / physiology*
Exercise Tolerance
Female
Heart Failure / metabolism*,  physiopathology
Humans
Male
Middle Aged
Muscle, Skeletal / metabolism*
Oxygen / pharmacokinetics
Oxygen Consumption*
Pulmonary Gas Exchange
Reference Values
Spectroscopy, Near-Infrared
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Electrical alternans during rest and exercise as predictors of vulnerability to ventricular arrhythm...
Next Document:  Automated assessment of mitral regurgitant volume and regurgitant fraction by a newly developed digi...