Document Detail


Skeletal muscle oxidative capacity and exercise tolerance in rats with heart failure.
MedLine Citation:
PMID:  11283428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Past research has shown the development of exercise intolerance after myocardial infarction (MI). The purpose of this study was to test the hypothesis that reductions in oxidative enzyme activity, in a variety of skeletal muscles, coincide with the development of exercise intolerance in a rat model of chronic heart failure (CHF) induced by MI. METHODS: The animals were initially divided into two groups: sham-operated controls (Sham) and animals in which a MI was surgically induced. MI rats were then subdivided into two groups according to left ventricular end-diastolic pressure (LVEDP): <20 mm Hg [small MI (SMI)] and > 20 mm Hg [large MI (LMI)]. Exercise tolerance was measured by performing a progressive run to fatigue test (RTF). Citrate synthase (CS), 3-hydroxyacyl CoA dehydrogenase (HADH), and malate dehydrogenase (MDH) activities were measured in six hindlimb muscles. RESULTS: After approximately 6 wk of recovery, LVEDP differed among groups (P < 0.05): Sham (1 +/- 1 mm Hg, N = 7), SMI (7 +/- 2 mm Hg, N = 7), and LMI (30 +/- 2 mm Hg, N = 6). RTF was 20 +/- 1 min for Sham, 25 +/- 3 min for SMI, and 11 +/- 2 min for LMI (P < 0.05 for LMI vs Sham, SMI). Significant reductions in enzyme activity were found for all three enzymes in the red portion of the gastrocnemius muscles of LMI. However, no significant correlation was found between RTF and CS, HADH, or MDH in any muscle of the three groups of animals. DISCUSSION: The results of the present study demonstrate that severe left ventricular dysfunction is associated with reductions in exercise tolerance and modest decreases in oxidative enzyme activities in selected muscles. It does not appear, however, that the development of exercise intolerance in CHF and oxidative enzyme activities are mechanistically related to one another.
Authors:
P C Pfeifer; T I Musch; R M McAllister
Related Documents :
9572798 - Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart ...
16873938 - Coenzyme q10 improves contractility of dysfunctional myocardium in chronic heart failure.
16310408 - Ve/vco2 slope is associated with abnormal resting haemodynamics and is a predictor of l...
9189148 - Ambulatory monitoring of left ventricular function: walk and bicycle exercise in conges...
17201928 - Estimation of the stress related to conservative scoliosis therapy: an analysis based o...
23312728 - A comparison of electromyography of gluteus medius and maximus in subjects with and wit...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  33     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-03     Completed Date:  2001-05-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-8     Citation Subset:  IM; S    
Affiliation:
Department of Kinesiology, Kansas State University, Manhattan, KS 66506, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Analysis of Variance
Animals
Citrate (si)-Synthase / metabolism
Disease Models, Animal
Exercise Test
Exercise Tolerance / physiology*
Hemodynamics
Malate Dehydrogenase / metabolism
Male
Muscle Fatigue / physiology
Muscle, Skeletal / enzymology*
Myocardial Infarction / physiopathology*
Rats
Rats, Wistar
Ventricular Dysfunction, Left / physiopathology
Grant Support
ID/Acronym/Agency:
HL57226/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 1.1.1.37/Malate Dehydrogenase; EC 2.3.3.1/Citrate (si)-Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of strength training on resting metabolic rate and physical activity: age and gender comparis...
Next Document:  Anaerobic exercise induces moderate acute phase response.