Document Detail

Skeletal muscle morphology in patients with restless legs syndrome.
MedLine Citation:
PMID:  17622717     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of the study was to assess the cellular and structural properties of skeletal muscle in restless legs syndrome (RLS). METHOD: Twenty patients and 16 controls were included. Aerobic performance was assessed using a submaximal test. On muscle biopsies taken from the tibialis anterior, fiber distribution and fiber area were analyzed together with parameters surveying the microvascularization, especially the tortuosity, which is expressed as a percent of muscle fiber perimeter in contact with the wall of the microvessel, length of capillary/perimeter of fiber (LC/PF) index. RESULTS: The RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (p = 0.01) compared to the controls. CONCLUSION: The higher capillary tortuosity in RLS patients indicates the occurrence of significant remodeling in capillary geometry in RLS.
Britta Wåhlin Larsson; Fawzi Kadi; Jan Ulfberg; Karin Piehl Aulin
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Publication Detail:
Type:  Journal Article     Date:  2007-06-29
Journal Detail:
Title:  European neurology     Volume:  58     ISSN:  1421-9913     ISO Abbreviation:  Eur. Neurol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-15     Completed Date:  2007-11-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Department of Health and Social Sciences, Dalarna University, Falun, Sweden.
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MeSH Terms
Antigens, CD31 / metabolism
Capillaries / metabolism,  pathology
Microcirculation / cytology,  metabolism,  pathology
Middle Aged
Muscle Fibers, Skeletal / metabolism,  pathology
Muscle, Skeletal / metabolism,  pathology*
Myosin Heavy Chains / metabolism
Oxygen Consumption / physiology
Physical Exertion / physiology
Restless Legs Syndrome / pathology*
Reg. No./Substance:
0/Antigens, CD31; 0/Myosin Heavy Chains

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