Document Detail

Skeletal muscle metabolic recovery following submaximal exercise in chronic heart failure is limited more by O(2) delivery than O(2) utilization.
MedLine Citation:
PMID:  20310084     Owner:  NLM     Status:  MEDLINE    
CHF (chronic heart failure) is associated with a prolonged recovery of skeletal muscle energy stores following submaximal exercise, limiting the ability to perform repetitive daily activities.However, the pathophysiological background of this impairment is not well established. The aim of the present study was to investigate whether muscle metabolic recovery following submaximal exercise in patients with CHF is limited by O2 delivery or O2 utilization. A total of 13 stable CHF patients (New York Heart Association classes II-III) and eight healthy subjects, matched for age and BMI (body mass index), were included. All subjects performed repetitive submaximal dynamic single leg extensions in the supine position. Post-exercise PCr (phosphocreatine) resynthesis was assessed by 31P-MRS (magnetic resonance spectroscopy). NIRS (near-IR spectroscopy) was applied simultaneously, using the rate of decrease in HHb (deoxygenated haemoglobin) as an index of post-exercise muscle re-oxygenation. As expected, PCr recovery was slower in CHF patients than in control subjects (time constant, 47+/-10 compared with 35+/-12 s respectively; P=0.04). HHb recovery kinetics were also prolonged in CHF patients (mean response time, 74+/-41 compared with 44+/-17 s respectively; P=0.04). In the patient group, HHb recovery kinetics were slower than PCr recovery kinetics (P=0.02), whereas no difference existed in the control group(P=0.32). In conclusion, prolonged metabolic recovery in CHF patients is associated with an even slower muscle tissue re-oxygenation, indicating a lower O(2) delivery relative to metabolic demands. Therefore we postulate that the impaired ability to perform repetitive daily activities in these patients depends more on a reduced muscle blood flow than on limitations in O(2) utilization.
Hareld M C Kemps; Jeanine J Prompers; Bart Wessels; Wouter R De Vries; Maria L Zonderland; Eric J M Thijssen; Klaas Nicolay; Goof Schep; Pieter A F M Doevendans
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-26
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  118     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  IM    
Department of Cardiology, M?xima Medical Centre, Veldhoven, Netherlands.
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MeSH Terms
Case-Control Studies
Chronic Disease
Exercise / physiology
Heart Failure / physiopathology*
Hemoglobins / metabolism
Middle Aged
Muscle, Skeletal / physiology*
Oxygen / metabolism
Oxygen Consumption / physiology*
Phosphocreatine / metabolism
Reg. No./Substance:
0/Hemoglobins; 67-07-2/Phosphocreatine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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