Document Detail


Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: a point-counterpoint discussion.
MedLine Citation:
PMID:  15678622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.
Authors:
Eric P Brass; William R Hiatt; Simon Green
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  9     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-01-31     Completed Date:  2006-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-301     Citation Subset:  IM    
Affiliation:
Center for Clinical Pharmacology, Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Exercise Tolerance*
Humans
Intermittent Claudication / metabolism,  physiopathology
Leg / blood supply,  physiopathology
Muscle, Skeletal / blood supply,  metabolism*,  physiopathology*
Oxygen Consumption
Peripheral Vascular Diseases / metabolism*,  physiopathology*
Regional Blood Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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