Document Detail


Skeletal muscle: master or slave of the cardiovascular system?
MedLine Citation:
PMID:  10647534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skeletal muscle and cardiovascular system responses to exercise are so closely entwined that it is often difficult to determine the effector from the affector. The purpose of this manuscript and its companion papers is to highlight (and perhaps assist in unraveling) the interdependency between skeletal muscle and the cardiovascular system in both chronic and acute exercise. Specifically, we elucidate four main areas: 1) how a finite cardiac output is allocated to a large and demanding mass of skeletal muscle, 2) whether maximal muscle oxygen uptake is determined peripherally or centrally, 3) whether blood flow or muscle metabolism set the kinetic response to the start of exercise, and 4) the matching of structural adaptations in muscle and the microcirculation in response to exercise. This manuscript, the product of an American College of Sports Medicine Symposium, unites the thoughts and findings of four researchers, each with different interests and perspectives, but with the common intent to better understand the interaction between oxygen supply and metabolic demand during exercise.
Authors:
R S Richardson; C A Harms; B Grassi; R T Hepple
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  32     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-10     Completed Date:  2000-02-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, University of California, San Diego, La Jolla 90293-0623, USA. rrichardson@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Cardiac Output / physiology
Cardiovascular Physiological Phenomena*
Exercise / physiology*
Humans
Microcirculation / physiology
Mitochondria, Muscle / metabolism
Muscle, Skeletal / blood supply,  metabolism,  physiology*
Oxygen Consumption / physiology
Regional Blood Flow / physiology
Grant Support
ID/Acronym/Agency:
17731//PHS HHS; HL-15469/HL/NHLBI NIH HHS; RR02305/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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