Document Detail


Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women.
MedLine Citation:
PMID:  7781930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Regional fat distribution is an important determinant of insulin resistance in obesity. In the current study, the relationship between skeletal muscle insulin sensitivity, mid-thigh muscle composition, and the metabolic profile of muscle was investigated. Muscle composition was assessed by computed tomography of the mid-thigh, and by activities of marker enzymes of aerobic-oxidative and glycolytic pathways and muscle fiber typing using biopsies of the vastus lateralis muscle. Muscle with reduced Hounsfield attenuation on computed tomography scans was increased in proportion to obesity, and was strongly related to insulin resistance, reduced muscle oxidative capacity, and increased anaerobic and glycolytic capacities by muscle. These findings suggest that as part of its expression of insulin resistance, skeletal muscle of obese individuals is also poorly equipped for substrate oxidation and manifests increased storage of fat.
Authors:
J A Simoneau; S R Colberg; F L Thaete; D E Kelley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  9     ISSN:  0892-6638     ISO Abbreviation:  FASEB J.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-07-18     Completed Date:  1995-07-18     Revised Date:  2012-02-15    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Affiliation:
Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA.
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Adenosine Triphosphatases / metabolism
Adipose Tissue / anatomy & histology
Adult
Aerobiosis
Blood Glucose / drug effects,  metabolism
Body Mass Index
Citrate (si)-Synthase / metabolism
Creatine Kinase / metabolism
Electron Transport Complex IV / metabolism
Female
Glucose / metabolism
Glucose Clamp Technique
Glyceraldehyde-3-Phosphate Dehydrogenases / metabolism
Glycolysis*
Hexokinase / metabolism
Humans
Infusions, Intravenous
Insulin / administration & dosage,  pharmacology*
Muscle Fibers, Skeletal / cytology,  physiology
Muscle, Skeletal / cytology,  enzymology,  physiology*
Obesity / enzymology,  physiopathology*
Phosphofructokinase-1 / metabolism
Phosphorylases / metabolism
Thinness
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
1P30DK46204/DK/NIDDK NIH HHS; 5MO1RR00056/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 50-99-7/Glucose; EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 1.2.1.-/Glyceraldehyde-3-Phosphate Dehydrogenases; EC 1.9.3.1/Electron Transport Complex IV; EC 2.3.3.1/Citrate (si)-Synthase; EC 2.4.1.-/Phosphorylases; EC 2.7.1.1/Hexokinase; EC 2.7.1.11/Phosphofructokinase-1; EC 2.7.3.2/Creatine Kinase; EC 3.6.1.-/Adenosine Triphosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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