Document Detail


Skeletal muscle fatty acid transport and transporters.
MedLine Citation:
PMID:  9781326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long-chain fatty acids (LCFAs) are an important energy source for many tissues. The dogma that LCFAs are freely diffusible has been challenged. It is now known that LCFAs are transported into many tissues. Our studies have shown that LCFAs are also transported into skeletal muscle and into the heart. In recent years a number of putative fatty acid transport proteins have been identified. These are known as plasma membrane fatty acid binding protein (FABPpm, 43 kDa), fatty acid translocase (FAT, 88 kDa) and fatty acid transporter protein (FATP, 63 kDa). All three proteins are present in skeletal muscle and in the heart. The existence of an LCFA transport system in muscle may be essential 1) to facilitate the rapid and regulatable transport of LCFA to meet the metabolic requirements of working muscles and 2) to cope with an increase in circulating LCFAs in some pathological conditions (e.g. diabetes). There is now some evidence that metabolic changes and chronically increased muscle activity can increase the transport of LCFAs and increase the expression of putative LCFA transporters.
Authors:
A Bonen; D J Dyck; J J Luiken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  441     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-01     Completed Date:  1998-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-205     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, University of Waterloo, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Carrier Proteins / metabolism*
Cell Membrane
Fatty Acid-Binding Proteins
Fatty Acids / metabolism*
Humans
Muscle, Skeletal / metabolism*
Myelin P2 Protein / metabolism*
Neoplasm Proteins*
Tumor Suppressor Proteins*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/FABP7 protein, human; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/Myelin P2 Protein; 0/Neoplasm Proteins; 0/Tumor Suppressor Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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