Document Detail

Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans.
MedLine Citation:
PMID:  21135050     Owner:  NLM     Status:  MEDLINE    
The mechanisms determining exercise intolerance are poorly understood. A reduction in work efficiency in the form of an additional energy cost and oxygen requirement occurs during high-intensity exercise and contributes to exercise limitation. Muscle fatigue and subsequent recruitment of poorly efficient muscle fibres has been proposed to mediate this decline. These data demonstrate in humans, that muscle fatigue, generated in the initial minutes of exercise, is correlated with the increasing energy demands of high-intensity exercise. Surprisingly, however, while muscle fatigue reached a plateau, oxygen uptake continued to increase throughout 8 min of exercise. This suggests that additional recruitment of inefficient muscle fibres may not be the sole mechanism contributing to the decline in work efficiency during high-intensity exercise.
Daniel T Cannon; Ailish C White; Melina F Andriano; Fred W Kolkhorst; Harry B Rossiter
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-12-06
Journal Detail:
Title:  The Journal of physiology     Volume:  589     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-05-27     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  727-39     Citation Subset:  IM    
Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
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MeSH Terms
Anaerobic Threshold / physiology
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology
Muscle Fatigue / physiology*
Muscle, Skeletal / physiology*
Oxygen Consumption / physiology*
Pulmonary Gas Exchange / physiology
Young Adult

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