Document Detail


Skeletal muscle deoxygenation during exercise assessed by near-infrared spectroscopy and its relation to expired gas analysis parameters.
MedLine Citation:
PMID:  9766702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was performed to determine the relation between oxygenated hemoglobin (oxy-Hb) changes in working muscles and ventilatory parameters. Six active normal subjects, 21 sedentary normal subjects and 16 patients with heart failure performed an incremental exercise with expired gas analysis. Deoxygenation of the vastus lateralis muscle was monitored for oxy-Hb changes using near-infrared spectroscopy. Near the anaerobic threshold (AT), oxy-Hb started to decrease, forming the first inflection point (P1). Near the respiratory compensation point (RCP), the second inflection point (P2) was observed. Oxygen uptake at the AT, RCP, P1 and P2 decreased in magnitude first in the active normal subjects, then in sedentary normal subjects and finally in the heart failure patients. High correlation was demonstrated between AT and P1 (r=0.8, p<0.0005) and between RCP and P2 (r=0.9, p<0.0005). In 12 sedentary normal subjects who underwent repeat exercise, reproducibility was confirmed for both P1 and P2. Constant work rate exercises were performed in 5 sedentary normal subjects, and in all of them the oxy-Hb remained unchanged below the AT work rate, whereas oxy-Hb decreased above the AT work rate. Exercise capacity, with respect to both working muscle deoxygenation and ventilation, could be evaluated in detail by the concomitant use of near-infrared spectroscopy and expired gas analysis.
Authors:
T Miura; T Takeuchi; H Sato; N Nishioka; S Terakado; Y Fujieda; C Ibukiyama
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  62     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-30     Completed Date:  1998-12-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  649-57     Citation Subset:  IM; S    
Affiliation:
Second Department of Internal Medicine, Tokyo Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anaerobiosis
Carbon Dioxide / analysis*
Exercise Test
Female
Heart Failure / metabolism,  physiopathology
Hemoglobins / analysis
Humans
Male
Middle Aged
Muscle, Skeletal / metabolism*
Oxygen / metabolism
Oxygen Consumption
Oxyhemoglobins / analysis*
Partial Pressure
Physical Exertion / physiology*
Physical Fitness
Reproducibility of Results
Spectrophotometry, Infrared*
Ventricular Dysfunction, Left / metabolism,  physiopathology
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin

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