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Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis.
MedLine Citation:
PMID:  21888528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It has been known for more than 4 decades that exercise causes increases in skeletal muscle mitochondrial enzyme content and activity (i.e., mitochondrial biogenesis). Increasing evidence now suggests that exercise can induce mitochondrial biogenesis in a wide range of tissues not normally associated with the metabolic demands of exercise. Perturbations in mitochondrial content and (or) function have been linked to a wide variety of diseases, in multiple tissues, and exercise may serve as a potent approach by which to prevent and (or) treat these pathologies. In this context, the purpose of this review is to highlight the effects of exercise, and the underlying mechanisms therein, on the induction of mitochondrial biogenesis in skeletal muscle, adipose tissue, liver, brain, and kidney.
Authors:
Jonathan P Little; Adeel Safdar; Carley R Benton; David C Wright
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-2
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme     Volume:  -     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Department of Biology, I.K. Barber School of Arts and Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
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