Document Detail

Skeletal changes in thalassemia major.
MedLine Citation:
PMID:  1797739     Owner:  NLM     Status:  MEDLINE    
The authors clinically and radiographically examined 72 patients with homozygous beta thalassemia. The clinical data were compared to the degree of osteoporosis calculated by Singh's method. The results indicate a high incidence of skeletal changes in patients with thalassemia, including lower limb-length discrepancy (16.6%), upper limb-length discrepancy (5.5%), axial deviation of the limbs (8.3%), osteochondrosis (2.7%), and osteopenia (25%). Based on their observations, the authors identify skeletal changes of adulthood (osteopenia) and childhood (limb-length discrepancy, axial deviation, osteochondrosis). The authors hypothesize that osteoporotic changes are caused principally by hyperplasia of the bone marrow, which widens the medullary space and increases intramedullary pressure, leading eventually to osteoporosis.
E Giuzio; M Bria; M G Bisconte; M Caracciolo; M Misasi; M Nastro; C Brancati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of orthopaedics and traumatology     Volume:  17     ISSN:  0390-5489     ISO Abbreviation:  Ital J Orthop Traumatol     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-04-13     Completed Date:  1992-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7511480     Medline TA:  Ital J Orthop Traumatol     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  269-75     Citation Subset:  IM    
Istituto di Chirurgia dell'Apparato Locomotore e Chirurgia d'Urgenza dell'Università, Napoli.
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MeSH Terms
Arm / abnormalities
Bone Diseases, Metabolic / etiology*,  radiography
Bone and Bones / pathology*,  radiography
Child, Preschool
Knee Joint / pathology
Leg Length Inequality / etiology,  radiography
Osteochondritis / etiology
Thalassemia / complications*,  pathology

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