| Skeletal Muscle Plasticity After Hemorrhagic Stroke in Rats: Influence of Spontaneous Physical Activity. | |
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MedLine Citation:
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PMID: 22760110 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to determine the contribution of spontaneous post-stroke physical activity to skeletal muscle plasticity after stroke. DESIGN: A randomized controlled study was conducted of 24 young adult male Sprague-Dawley rats assigned to three experimental groups: (1) STR-hemorrhagic stroke in the right caudoputamen; (2) SHAM-procedural control; and (3) CONT-no intervention (n = 8/group). Neurologic testing was performed before and 2 wks after stroke. Spontaneous physical activity was monitored five nights per week for 1 wk preoperatively and 2 wks postoperatively. Two weeks after stroke induction, bilateral soleus and tibialis anterior muscles were harvested. Myofiber cross-sectional areas were determined, and fiber typing was performed with immunohistochemistry. RESULTS: STR animals demonstrated neurologic deficit in the contralesional hindlimb 2 wks after stroke. Quantity of spontaneous physical activity did not differ between groups within each of the week-long study intervals. No significant difference was found in fiber types or cross-sectional areas in the soleus muscle of STR vs. CONT groups. However, the tibialis anterior muscle of the contralesional hindlimbs of the STR animals showed atrophy in 2x and 1 + 2x myofibers, as well as type 1 hypertrophy. CONCLUSIONS: Skeletal muscle adaptation occurs by 2 wks post-stroke in this model. It is muscle specific and appears to be influenced by factors other than spontaneous post-stroke physical activity. |
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Authors:
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Leann M Snow; Walter C Low; Ladora V Thompson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-29 |
Journal Detail:
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Title: American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Volume: - ISSN: 1537-7385 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-7-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803677 Medline TA: Am J Phys Med Rehabil Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Program in Physical Therapy (LMS, LVT) and Department of Neurosurgery (WCL), University of Minnesota, Minneapolis. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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