Document Detail

Skeletal Muscle Adaptation in Response to Supervised Exercise Training for Intermittent Claudication.
MedLine Citation:
PMID:  22841358     Owner:  NLM     Status:  Publisher    
OBJECTIVES: There is evidence that the improvement following supervised exercise for claudication results from skeletal muscle adaptation. The myosin heavy chain (MHC) determines muscle fibre type and therefore efficiency. Immunohistochemical analysis has failed to take account of hybrid MHC expression within myofibres. This study sought evidence of differential MHC protein expression following supervised exercise for claudication. DESIGN: 38 claudicants were recruited. Subjects undertook a three-month supervised exercise programme. Controls were patients awaiting angioplasty for claudication. MATERIALS AND METHODS: Subjects underwent paired gastrocnemius biopsy. Relative expression of MHC proteins was determined by SDS-PAGE electrophoresis. Non-parametric data is presented as median with the inter-quartile range and parametric as the mean ± standard deviation. RESULTS: Upon completion of the exercise programme there was a 94% increase (124 (106-145) to 241 (193-265) metres, p = 0.002) in maximum walking distance, which was not evident in the control group. An 11.1% (p = 0.02) increase in MHC I expression was observed in the exercise but not the control group (34.3% ± 6.8 to 45.4% ± 4.4). There was a positive correlation between the change in MHC I expression and the improvement in claudication distance (r = 0.69, p < 0.05). CONCLUSIONS: Supervised exercise training for claudication results in an increase in the proportion of MHC type I expression within the symptomatic gastrocnemius muscle.
T A Beckitt; J Day; M Morgan; P M Lamont
Related Documents :
22681608 - Baroreflex mechanisms and response to exercise in patients with heart disease.
22390738 - Self-regulatory processes mediate the intention-behavior relation for adherence and exe...
6759238 - Effect of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion.
21146958 - Low cardiorespiratory fitness and physical functional capacity in obese patients with s...
25275718 - Evaluation of a precise and measurable model for learning laparoscopic tissue handling.
2145238 - Effects of enoximone in patients with heart failure uncontrolled by captopril and diure...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  -     ISSN:  1532-2165     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
Department of Vascular Surgery, Bristol Royal Infirmary, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Decreasing the Delay to Carotid Endarterectomy in Symptomatic Patients with Carotid Stenosis - Outco...
Next Document:  Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease.