Document Detail

Sjogren's syndrome myelopathy: spinal cord involvement in Sjogren's syndrome might be a manifestation of neuromyelitis optica.
MedLine Citation:
PMID:  19692434     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate clinical characteristics, aquaporin (AQP)-4 antibody results, and probability of developing symptoms of neuromyelitis optica (NMO) in patients with Sjögren's syndrome myelopathy (SSM). METHODS: We identified eight patients with spinal cord involvement from 112 patients with Sjögren's syndrome (SS) referred to the neurology department. The clinical characteristics and AQP-4 antibody status, based on immunoprecipitation of EGFP-tagged AQP-4, of the patients with SSM were assessed. RESULTS: All patients with SSM had extensive spinal cord lesions, high mean annual relapse rates, and poor response to steroid treatment. Of the eight patients with SSM, seven patients satisfied the revised diagnostic criteria for NMO or showed positive results from AQP-4 antibody testing; one patient had incomplete follow-up. The clinical manifestations and AQP-4 autoantibody status of patients with SSM did not differ significantly from those of NMO patients without SS. CONCLUSION: All patients with SSM had poor prognosis with high mean annual relapse rates, and most seemed to have the clinical and immunological characteristics of NMO. Early aggressive immune therapies should be considered in patients with SSM irrespective of the presence or absence of optic neuritis.
S M Kim; P Waters; A Vincent; S Y Kim; H J Kim; Y H Hong; K S Park; J H Min; J J Sung; K W Lee
Related Documents :
8423204 - Htlv-1 antibody class and subclass distribution in african tsp and control populations.
1662224 - Autoantibodies to native myeloperoxidase in patients with pulmonary hemorrhage and acut...
14670284 - Humoral immunity in pediatric patients with acute lymphoblastic leukaemia.
1568274 - Dengue haemorrhagic fever in children in delhi.
21324124 - Modified mallampati classification as a clinical predictor of peroral esophagogastroduo...
1411764 - Prevalence of scoliosis in children with myelomeningocele in western sweden.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  15     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-20     Completed Date:  2009-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  1062-8     Citation Subset:  IM    
Department of Neurology, Seoul National University, College of Medicine, Seoul, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age of Onset
Aquaporin 4 / metabolism
Brain / metabolism,  pathology
Magnetic Resonance Imaging
Middle Aged
Myelin Sheath / metabolism,  pathology*
Neuromyelitis Optica / drug therapy,  metabolism,  pathology*
Retrospective Studies
Sjogren's Syndrome / drug therapy,  metabolism,  pathology*
Spinal Cord / metabolism,  pathology*
Steroids / therapeutic use
Reg. No./Substance:
0/AQP4 protein, human; 0/Aquaporin 4; 0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multiple sclerosis, immunomodulators, and pregnancy outcome: a prospective observational study.
Next Document:  Multiple sclerosis and neurofibromatosis type 1: report of seven patients from Iran.