Document Detail

Size variance of motor evoked potential at initiation of voluntary contraction in palsy of conversion disorder.
MedLine Citation:
PMID:  18588588     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the efficacy of transcranial magnetic stimulation (TMS) with a cue signal for the objective diagnosis of palsy of conversion disorder (CD). METHODS: Ten patients with palsy of CD, nine with amyotrophic lateral sclerosis (ALS), and eight control subjects were examined. Motor evoked potential (MEP) was recorded from the abductor digiti minimi muscle under three conditions: at rest, during tonic contraction, and with an audio cue signal. In the cue signal paradigm, subjects were asked to perform ramp-and-hold contraction in response to a cue signal. RESULTS: MEP size increased in the cue signal paradigm in both controls and patients with ALS, but was not obvious in some CD patients. This was likely due to variance among trials in the cue signal paradigm in each CD patient. The coefficients of variance (CV) among trials in the cue signal paradigm were 15 +/- 4.3 in controls, 25 +/- 11 in ALS, and 70 +/- 40 in CD. CONCLUSIONS: CV of MEP size with cue signal was larger in CD than in controls (P < 0.005) and in ALS patients (P < 0.01). The size variance among MEP trials with the cue signal is a supportive parameter for the diagnosis of CD.
Hiroshi Morita; Yoshio Shimojima; Noriko Nishikawa; Naoki Hagiwara; Naoji Amano; Shu-ichi Ikeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry and clinical neurosciences     Volume:  62     ISSN:  1440-1819     ISO Abbreviation:  Psychiatry Clin. Neurosci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9513551     Medline TA:  Psychiatry Clin Neurosci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  286-92     Citation Subset:  IM    
Department of Medicine-Neurology, Shinshu University School of Medicine, Asahi, Matsumoto, Japan.
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MeSH Terms
Amyotrophic Lateral Sclerosis / diagnosis,  physiopathology,  psychology
Conversion Disorder / diagnosis*,  physiopathology*
Diagnosis, Differential
Evoked Potentials, Motor / physiology*
Isometric Contraction / physiology*
Middle Aged
Paralysis / diagnosis*,  psychology*
Reaction Time / physiology
Reference Values
Signal Processing, Computer-Assisted

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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