Document Detail

Size and surface charge effect of 5-aminolevulinic acid-containing liposomes on photodynamic therapy for cultivated cancer cells.
MedLine Citation:
PMID:  16207609     Owner:  NLM     Status:  MEDLINE    
5-Aminolevulinic acid (ALA)-containing liposomes having various average diameters and/or positive surface charges were prepared, and their photodynamic therapy (PDT) efficacy for murine thymic lymphoma cells, EL-4 cells, cultivated in vitro was investigated. The PDT efficacy for EL-4 cells and the accumulation of ALA-induced protoporphyrin IX (PpIX) in the cells increased with a decrease in the average diameter of liposomes. In particular, the ALA-containing liposomes smaller than 63.5 nm in diameter promoted the PDT efficacy in comparison with that of ALA alone. We also found no significant changes in PDT efficacy and PpIX accumulation with increasing positive surface charges of liposomes.
Toshiyuki Kosobe; Eiji Moriyama; Yoshikazu Tokuoka; Norimichi Kawashima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  31     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-10-06     Completed Date:  2006-07-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  623-9     Citation Subset:  IM    
Faculty of Engineering, Toin University of Yokohama, Yokohama, Japan.
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MeSH Terms
Aminolevulinic Acid / administration & dosage*
Cell Line, Tumor
Cell Survival / drug effects
Particle Size
Photosensitizing Agents / administration & dosage*,  metabolism
Protoporphyrins / metabolism
Surface Properties
Reg. No./Substance:
0/Liposomes; 0/Photosensitizing Agents; 0/Protoporphyrins; 106-60-5/Aminolevulinic Acid; 553-12-8/protoporphyrin IX

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