| Size and surface charge effect of 5-aminolevulinic acid-containing liposomes on photodynamic therapy for cultivated cancer cells. | |
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MedLine Citation:
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PMID: 16207609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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5-Aminolevulinic acid (ALA)-containing liposomes having various average diameters and/or positive surface charges were prepared, and their photodynamic therapy (PDT) efficacy for murine thymic lymphoma cells, EL-4 cells, cultivated in vitro was investigated. The PDT efficacy for EL-4 cells and the accumulation of ALA-induced protoporphyrin IX (PpIX) in the cells increased with a decrease in the average diameter of liposomes. In particular, the ALA-containing liposomes smaller than 63.5 nm in diameter promoted the PDT efficacy in comparison with that of ALA alone. We also found no significant changes in PDT efficacy and PpIX accumulation with increasing positive surface charges of liposomes. |
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Authors:
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Toshiyuki Kosobe; Eiji Moriyama; Yoshikazu Tokuoka; Norimichi Kawashima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: 31 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-10-06 Completed Date: 2006-07-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: United States |
Other Details:
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Languages: eng Pagination: 623-9 Citation Subset: IM |
Affiliation:
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Faculty of Engineering, Toin University of Yokohama, Yokohama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminolevulinic Acid
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administration & dosage* Animals Cell Line, Tumor Cell Survival / drug effects Liposomes Mice Particle Size Photochemotherapy* Photosensitizing Agents / administration & dosage*, metabolism Protoporphyrins / metabolism Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Liposomes; 0/Photosensitizing Agents; 0/Protoporphyrins; 106-60-5/Aminolevulinic Acid; 553-12-8/protoporphyrin IX |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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