Document Detail


Size of the nanovectors determines the transplacental passage in pregnancy: study in rats.
MedLine Citation:
PMID:  21481834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of the study was to examine whether the size of silicon nanovectors (SNVs) inhibits their entrance into the fetal circulation.
STUDY DESIGN: Pregnant rats were intravenously administered with SNVs or saline. The SNVs were spherical particles with 3 escalating diameters: 519 nm, 834 nm, and 1000 nm. The maternal and fetal distribution of SNVs was assessed.
RESULTS: In animals that received 1000 or 834 nm SNV, silicon (Si) levels were significantly higher in the maternal organs vs the saline group, whereas the silicon levels in fetal tissues were similar to controls. However, in animals receiving 519 nm SNVs, fetal silicon levels were significantly higher in the SNV group compared with the saline group (5.93 ± 0.67 μg Si per organ vs 4.80 ± 0.33, P = .01).
CONCLUSION: Larger SNVs do not cross the placenta to the fetus and, remaining within the maternal circulation, can serve as carriers for harmful medications in order to prevent fetal exposure.
Authors:
Jerrie S Refuerzo; Biana Godin; Karen Bishop; Srimeenakshi Srinivasan; Shinil K Shah; Sarah Amra; Susan M Ramin; Mauro Ferrari
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-08
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  204     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-14     Completed Date:  2011-09-15     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  546.e5-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Nanoparticles*
Particle Size
Placenta / metabolism*
Pregnancy
Rats
Rats, Sprague-Dawley
Silicon / metabolism*
Grant Support
ID/Acronym/Agency:
KL2 RR0224149/RR/NCRR NIH HHS; TL1 RR024147/RR/NCRR NIH HHS; TL1 RR024147/RR/NCRR NIH HHS; TL1 RR024147-01/RR/NCRR NIH HHS; UL1 RR024148/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
Z4152N8IUI/Silicon
Comments/Corrections

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