Document Detail


Size-dependent tumor penetration and in vivo efficacy of monodisperse drug-silica nanoconjugates.
MedLine Citation:
PMID:  23301497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The size of a nanomedicine strongly correlates with its biodistribution, tissue penetration, and cell uptake. However, there is limited understanding how the size of nanomedicine impacts the overall antitumor efficacy. We designed and synthesized camptothecin-silica nanoconjugates (Cpt-NCs) with monodisperse particle sizes of 50 and 200 nm, two representative sizes commonly used in drug delivery, and evaluated their antitumor efficacy in murine tumor models. Our studies revealed that the 50 nm Cpt-NC showed higher anticancer efficacy than the larger analogue, due presumably to its faster cellular internalization and more efficient tumor accumulation and penetration. Our findings suggest that nanomedicine with smaller sizes holds great promise for improved cancer therapy.
Authors:
Li Tang; Nathan P Gabrielson; Fatih M Uckun; Timothy M Fan; Jianjun Cheng
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-02-12
Journal Detail:
Title:  Molecular pharmaceutics     Volume:  10     ISSN:  1543-8392     ISO Abbreviation:  Mol. Pharm.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-04     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101197791     Medline TA:  Mol Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  883-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Camptothecin / chemistry*
Cell Line, Tumor
Drug Delivery Systems / methods
Female
HeLa Cells
Humans
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Nude
Microscopy, Confocal
Nanoconjugates / administration & dosage,  chemistry*
Silicon Dioxide / chemistry*
Grant Support
ID/Acronym/Agency:
1DP2OD007246-01/OD/NIH HHS; 1R21CA152627/CA/NCI NIH HHS; DP2 OD007246/OD/NIH HHS; R21 CA152627/CA/NCI NIH HHS; R25 CA154015A/CA/NCI NIH HHS; U01 CA151837/CA/NCI NIH HHS; U01-CA-151837/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Nanoconjugates; 7631-86-9/Silicon Dioxide; XT3Z54Z28A/Camptothecin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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