| Size-dependent myelinated fiber loss in the corticospinal tract in Shy-Drager syndrome and amyotrophic lateral sclerosis. | |
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MedLine Citation:
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PMID: 3822153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morphometric evaluation was performed on myelinated fibers of the corticospinal tract at the seventh thoracic spinal cord segment from three patients with Shy-Drager syndrome (SDS), six patients with amyotrophic lateral sclerosis (ALS), and five patients with nonneurologic symptoms. In SDS, small-sized myelinated fibers were nearly completely depleted, while large-sized myelinated fibers were considerably well preserved. In ALS, on the contrary, large myelinated fibers were predominantly decreased. These results suggested that selective vulnerability of axonal loss depends on fiber size and should be considered in interpretation of pathology of corticospinal tracts. |
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Authors:
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G Sobue; Y Hashizume; T Mitsuma; A Takahashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology Volume: 37 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-04-08 Completed Date: 1987-04-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 529-32 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amyotrophic Lateral Sclerosis
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pathology* Autonomic Nervous System Diseases / pathology* Axons / pathology Female Humans Male Middle Aged Nerve Fibers, Myelinated / pathology* Pyramidal Tracts / pathology* Shy-Drager Syndrome / pathology* |
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